ANTITUMOR ACTIVITY OF CISPLATIN ANALOGS AGAINST MALIGNANT OVARIAN TUMOR XENOGRAFTS INTO NUDE MICE
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概要
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当教室で継代されているヒト卵巣悪性腫瘍ヌードマウス移植系2株 (漿液性嚢胞腺癌: OH-1, ムチン性嚢胞腺腫, 低悪性度群: MP-1) を用いて, シスプラチン(CDDP)およびその誘導体 (JM-8, 254-S, DWA2114R) の抗腫瘍効果を検討した. OH-1のT/C比による検討では, 最低値は順次示すごとくCDDP, 8.41%, 254-S, 5.93%, JM-8, 6.57%, DWA2114R, 27.8%であつた. また, 各種薬剤間の統計学的検討ではJM-8, 254-Sが最も有効な薬剤と考えられた. 一方, MP-1の腹部直径比による検討ではJM-8投与群で最も効果がみられた. さらに血清CEA値による検討ではJM-8, CDDPが有効と思われ, 本株ではJM-8, CDDPが有効な薬剤と考えられた. また, 両株における組織学的効果は多岐にわたつており, 各群の比較は困難であつた. 今回, 担癌マウスの治療中における体重減少率を副作用の代用としたが, 254-S投与群で最も体重減少が著明であつた. 以上より卵巣悪性腫瘍において将来, 組織型をふまえた化学療法の必要性が示唆された.
- 社団法人日本産科婦人科学会の論文
- 1988-11-01
著者
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Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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MATSUMURA Takashi
Department of Mechanical Engineering; Tokyo Denki University
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Yakushiji M
Kurume Univ. Fukuoka Jpn
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Yakushiji Michiaki
久留米大学 産婦人科
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Yakushiji Michiaki
久留米大学 第1病理
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KATO Toshi
Department of Obstetrics and Gynecology. School of Medicine, Kurume University
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NISHIMURA Haruo
Departmelet of Gynecology and Obstetrics, Kurume University, Faculty of Medicine
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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HAMAGUCHI Kinya
Department of Obstetrics and Gynecology Kurume University School of Medicine
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MIYAHARA Kenichi
Department of Obstetrics and Gynecology Kurume University School of Medicine
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TASHIRO Masamichi
Department of Obstetrics and Gynecology Kurume University School of Medicine
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KISHI Nobuhiro
Department of Obstetrics and Gynecology Kurume University School of Medicine
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Kamura Toshihatu
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Matsumura Takashi
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Kato Toshi
Department Of Obstetrics And Gynecology. School Of Medicine Kurume University
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Kato Toshi
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Nishimura Haruo
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Matsumura Takashi
Department Of Mechanical Engineering & Intelligent Systems University Of Electro-communications
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Matsumura Takashi
Department Of Electronic Engineering Faculty Of Engineering Gunma University
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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