Association of Tubal Sterilization and Induced Abortion with Ovarian Cancer:Meta-analysis of Published Case-control Studies

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A meta-analysis was applied to the published case-control studies of ovarian cancer in order to examine the association of tubal sterilization and induced abortion with ovarian cancer. Among 65 case-control studies published between 1981 and 1991, six articles reported the numbers of women who underwent tubal sterilization and four articles reported the numbers ofwomen undergoing induced abortion in both cases and their controls. The test for combinability of these 6 or 4 odds ratios revealed that these odds ratios were combinable in terms of tubal sterilization or induced abortion. It was shown that tubal sterilization was significantly associated with a reduced risk for ovarian cancer (the summary odds ratio=0.55, 95% confidence interval or 95% CI 0.45-0.68), even after excluding nulliparous women from the analysis (the summary odds ratio=0.52, 95% Cl 0.36-0.74), and that induced abortion was also related to a decreased risk for ovarian cancer (the summary odds ratio=0.81, 95% Cl 0.63-1.04 based on the 4 combinable odds ratios; the summary odds ratio= 0.64, 95% Cl 0.46-0.89 based on the 2 studies in Asian countries). Several etiological inferences were made with regard to these findings, and some proposals for further research were addressed in ovarian cancer epidemiology. J Epidemiol, 1992; 2 : 111-118.
日本疫学会の論文