Blood Isoflavone Levels during Intake of a Controlled Hospital Diet
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概要
- 論文の詳細を見る
Isoflavones are reported to have an estrogenic activity to prevent prostate cancer. Therefore, it is necessary to analyze the factors influencing the absorption and metabolism of isoflavones using detailed and precise dietary information. We evaluated the relationship between the amount of intake of soybean isoflavones in the diet and its serum levels in 88 hospitalized patients (22 with prostate cancer, 66 without cancer) with a mean age of 67.0±9.3 y. The intake amount of genistein and daidzein was significantly lower in the hospital diet than that in the ordinary daily diet. The serum levels of isoflavones were related to the amount of intake consumed during the day before blood collection (r=0.27 for genistein, r=0.33 for daidzein), but not to the last meal before blood collection. While little relationship was observed between the amount of intake and serum levels of isoflavones in the equol producers, a marked relationship was noted in the non-producers (r=0.52 for genistein, r=0.67 for daidzein). Blood isoflavone levels decreased when the duration of the hospitalization was longer than 1 wk. These observations indicate that the serum isoflavone levels are correlated with the amount of intake of isoflavones during the preceding 2 wk and serve as an effective biomarker in individuals during the intake of the hospital diet. Further investigations, including the mechanism of the metabolism on isoflavones, are necessary for the evaluation of the preventive effect of isoflavones.
- 日本ビタミン学会の論文
著者
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MORI Mitsuru
Department of Public Health, Sapporo Medical University School of Medicine
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Mori Mitsuru
札幌医科大学 医学部公衆衛生学
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Mori Mitsuru
札幌医科大学 泌尿器科
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AKAZA HIDEYUKI
Department of Urology, University of Tsukuba
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AKAZA HIDEYUKI
University of Tsukuba
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Mori M
Sapporo Medical Univ. School Of Medicine Hokkaido Jpn
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Mori M
Department Of Epidemiology Sapporo Medical University School Of Medicine
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Akaza Hideyuki
Univ. Tsukuba Ibaraki Jpn
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Akaza Hideyuki
Urology Institute Of Clinical Medicine University Of Tsukuba
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Akaza Hideyuki
Department Of Urology Instiute Of Clinical Medicine University Of Tsukuba
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Akaza Hideyuki
St. Marianne Medical College
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MIYANAGA Naoto
Department of Urology, Institute of Clinical Medicine, Tsukuba University
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TAKASHIMA Naomi
Department of Urology, Institute of Clinical Medicine, Tsukuba University
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MIYANAGA Naoto
University of Tsukuba
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Mori Mitsuru
Department Of Community Health Science Saga Medical School
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Miyanaga Naoto
Univ. Tsukuba Ibaraki Jpn
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Miyanaga Naoto
Department Of Urology Institute Of Clinical Medicine University Of Tsukuba
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Nakahara Takahito
筑波大学 臨床医 泌尿器
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Akamatsu Hideki
Department Of Thoracic Cardiovascular Surgery Graduate School Of Medicine Tokyo Medical And Dental U
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KOMIYA Kimitoshi
Department of Nutritional Administration, Tsukuba University Hospital
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Akaza Hideyuki
Department Of Urology And Andrology Graduate School Of Comprehensive Human Sciences Tsukuba Universi
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Takashima Naomi
Department Of Urology University Of Tsukuba
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Miyanaga Naoto
Department Of Urology Graduate School Of Comprehensive Human Sciences Institute Of Clinical Medicine
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Komiya Kimitoshi
Department Of Nutritional Administration Tsukuba University Hospital
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Akaza Hideyuki
Departments Of Urology.university Of Tsukuba
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AKAZA Hideyuki
Department of Strategic Investigation on Comprehensive Cancer Network, Research Center for Advanced Science and Technology, The University of Tokyo
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