Antimitochondrial Antibody Negative Primary Biliary Cirrhosis in Japan : Utilization of Clinical Data When Patients Applied to Receive Public Financial Aid

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概要

• 論文の詳細を見る

• BACKGROUND: We examined patients who showed laboratory and histological evidence of primary biliary cirrhosis (PBC) in the absence of antimitochondrial antibody (AMA) to elucidate the characteristics of AMA negative PBC.METHODS: From a total of 5,805 patients with symptomatic PBC, 2,419 cases (41.7%) were selected in the present study, who were diagnosed using the following criterion; chronic non-suppurative destructive cholangitis was histologically observed and laboratory data did not contradict PBC. The information collected from records included sex, age, symptoms, physical findings, and complicated autoimmune diseases. We then evaluated these data according to the positivity of AMA.RESULTS: Of the total subjects, 470 cases (19.4%) were found to be negative for AMA. The proportion of female patients was higher among the AMA negative group than among the AMA positive one. Pruritus was found less frequently among patients with AMA negative PBC than among those with AMA positive PBC. Levels of alkaline phosphatase,γ-glutamyl transpeptidase, and IgM were significantly lower among patients with AMA negative PBC than among those with AMA positive PBC. Complications such as Sjögrens syndrome, rheumatoid arthritis, and scleroderma, including CREST syndrome, were found with significantly higher frequency among patients with AMA negative PBC than among those with AMA positive PBC.CONCLUSION: Considering serum level of IgM and frequencies of complicated autoimmune diseases, it is possible that Japanese patients with AMA negative PBC are consistent with the disease entity of autoimmune cholangitis reported in western countries.J Epidemiol 2006; 16: 30-34.

• 日本疫学会の論文
• 2006-01-01

著者

• MORI Mitsuru

  Department of Public Health, Sapporo Medical University School of Medicine

• SAKAUCHI Fumio

  Department of Public Health, Sapporo Medical University School of Medicine

• TODA Gotaro

  Senpo Tokyo Takanawa Hospital

• ZENIYA Mikio

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University Schoo

• Toda Gotaro

  東京慈恵会医科大学 消化器肝臓内科

• Toda G

  Division Of Gastroenterology And Hepatology Department Of Internal Medicine Jikei University School

• Sakauchi Fumio

  Department Of Public Health Sapporo Medical University School Of Medicine

• Sakauchi Fumio

  札幌医科大学 医学部公衆衛生学

• Toda G

  Jikei Univ. School Of Medicine Tokyo Jpn

• Toda Gotaro

  Division Of Gastroenterology And Hepatology Jikei University Hospital

• 銭谷 幹男

  Division Of Gastroenterology And Hepatology Department Of Internal Medicine The Jikei University Sch

• Mori Mitsuru

  Department Of Community Health Science Saga Medical School

• Zeniya M

  Division Of Gastroenterology And Hepatology Department Of Internal Medicine Jikei University School

• Zeniya Mikio

  Division Of Gastroenterology And Hepatology Department Of Internal Medicine Jikei University School

• ZENIYA Mikio

  Division of Gastoroenterology and Hepatology, Department of Internal Medicine, JIKEI University School of Medicine

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