An Overview of Genetic Polymorphisms and Pancreatic Cancer Risk in Molecular Epidemiologic Studies
スポンサーリンク
概要
- 論文の詳細を見る
Background: Although pancreatic cancer has been extensively studied, few risk factors have been identified, and no validated biomarkers or screening tools exist for early detection in asymptomatic individuals. We present a broad overview of molecular epidemiologic studies that have addressed the relationship between pancreatic cancer risk and genetic polymorphisms in several candidate genes and suggest avenues for future research.Methods: A comprehensive literature search was performed using the PubMed database.Results: Overall, individual polymorphisms did not seem to confer great susceptibility to pancreatic cancer; however, interactions of polymorphisms in carcinogen-metabolizing genes, DNA repair genes, and folate-metabolizing genes with smoking, diet, and obesity were shown in some studies. The major problem with these studies is that, due to small sample sizes, they lack sufficient statistical power to explore gene–gene or gene–environment interactions. Another important challenge is that the measurement of environmental influence needs to be improved to better define gene–environment interaction. It is noteworthy that 2 recent genome-wide association studies of pancreatic cancer have reported that variants in ABO blood type and in 3 other chromosomal regions are associated with risk for this cancer, thus providing new insight into pancreatic cancer etiology.Conclusions: As is the case in other complex diseases, common, low-risk variants in different genes may act collectively to confer susceptibility to pancreatic cancer in individuals with repeated environmental exposures, such as smoking and red meat intake. Clarification of gene–gene and gene–environmental interaction is therefore indispensable for future studies. To address these issues, a rigorously designed molecular epidemiologic study with a large sample is desirable.
- 日本疫学会の論文
- 2011-01-01
著者
-
WAKAI Kenji
Department of Clinical Epidemiology, University of Occupational and Environmental Health
-
Lin Y
Department Of Public Health-health Information Dynamics Field Of Social Life Science Nagoya Universi
-
Wakai K
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Wakai Kenji
愛知医科大学 医学部公衆衛生学講座
-
Wakai Kenji
愛知県がんセンター研究所 疫学予防部
-
Mori Mitsuru
札幌医科大学 医学部公衆衛生学
-
Mori Mitsuru
札幌医科大学 泌尿器科
-
Tamakoshi Akiko
Department Of Health Science Shiga University Of Medical Science
-
Kikuchi S
Aichi Medical Univ. Aichi Jpn
-
Kikuchi Shogo
愛知医科大学 医学部公衆衛生学講座
-
Kikuchi S
Juntendo Univ. School Of Medicine Jpn
-
LIN Yingsong
Department of Public Health, Aichi Medical University School of Medicine
-
Kurisu Yoko
武庫川女子大学 生活環境学部
-
Tamakoshi Akiko
京都府立医科大学 地域保健医療疫学
-
Mori M
Sapporo Medical Univ. School Of Medicine Hokkaido Jpn
-
Yingsong Lin
愛知医科大学 医学部公衆衛生学
-
Yagyu Kiyoko
Department Of Public Health Aichi Medical University School Of Medicine
-
Yagyu Kiyoko
Department Of Public Health Aichi Medical University
-
EGAWA NAOTO
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital
-
Mori M
Department Of Epidemiology Sapporo Medical University School Of Medicine
-
HOSONO Satoyo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
-
Mori Mitsuru
Department Of Community Health Science Saga Medical School
-
Egawa Naoto
Department Of Internal Medicine Tokyo Metropolitan Komagome Hospital
-
Hosono Satoyo
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Tamakoshi Akiko
Department Of Clinical Trials National Center For Geriatrics And Gerontology
-
Nakamura Kozue
Department Of Epidemiology And Preventive Medicine Gifu University Graduate School Of Medicine
-
Kikuchi Shogo
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
-
Nakao Haruhisa
Division Of Gastroenterology Department Of Internal Medicine Aichi Medical University
-
Wakai Kenji
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Ishii Hiroshi
Hepatobiliary And Pancreatic Section Gastroenterological Division Cancer Institute Hospital
-
UENO Makoto
Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center Hospital
-
Ueno Makoto
Hepatobiliary And Pancreatic Medical Oncology Division Kanagawa Cancer Center Hospital
-
Nakamura Kozue
Department Of Epidemiology & Preventive Medicine Gifu University Graduate School Of Medicine
-
Lin Yingsong
Department Of Public Health Aichi Medical University School Of Medicine
-
Nakao Haruhisa
Division Of Gastroenterology Department Of Internal Medicine Aichi Medical University School Of Medi
関連論文
- Association of Serum Phytoestrogen Concentration and Dietary Habits in a Sample Set of the JACC Study
- Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
- Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
- Dietary Risk Factors for Colon and Rectal Cancers : A Comparative Case-Control Study
- Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
- A Review of Food Frequency Questionnaires Developed and Validated in Japan
- Serum Pepsinogen Values and Helicobacter pylori Status among Control Subjects of a Nested Case-Control Study in the JACC study
- Diabetes mellitus and kidney cancer risk : The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
- Alcohol Consumption and Lung Cancer Mortality in Japanese Men : Results from Japan Collaborative Cohort (JACC) Study
- Association of Serum Carotenoid Concentration and Dietary Habits among the JACC Study Subjects
- Risk Factors for Kidney Cancer in a Japanese Population : Findings from the JACC Study
- Dietary Habits and Risk of Urothelial Cancer Incidence in the JACC Study
- Colorectal Cancer and Serum C-reactive Protein Levels : a Case-control Study Nested in the JACC Study
- Glucose Intolerance and Colorectal Cancer Risk in a Nested Case-Control Study among Japanese People
- Alcohol Consumption and Colorectal Cancer Risk : Findings from the JACC Study
- Medical History of Circulatory Diseases and Colorectal Cancer Death in the JACC Study
- Lung Cancer Mortality and Serum Levels of Carotenoids, Retinol, Tocopherols, and Folic Acid in Men and Women : a Case-Control Study Nested in the JACC Study
- Updated Information on Risk Factors for Lung Cancer : Findings from the JACC Study
- Dietary Habits and Risk of Lung Cancer Death in a Large-scale Cohort Study (JACC Study) in Japan by Sex and Smoking Habit
- Decrease in Risk of Lung Cancer Death in Males after Smoking Cessation by Age at Quitting : Findings from the JACC Study
- Tea Consumption and Lung Cancer Risk : A Case-Control Study in Okinawa, Japan
- Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
- Depressive Mood and Suicide Among Middle-Aged Workers : Findings from a Prospective Cohort Study in Nagoya, Japan
- CHANGES IN ACTIVITIES OF DAILY LIVING,PHYSICAL FITNESS, AND DEPRESSIVE SYMPTOMS AFTER SIX-MONTH PERIODIC WELL-ROUNDED EXERCISE PROGRAMS FOR OLDER ADULTS LIVING IN NURSING HOMES OR SPECIAL NURSING FACILITIES
- Association Between Low Birth Weight and Elevated White Blood Cell Count in Adulthood Within a Japanese Population
- Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers
- High-Sensitivity C-Reactive Protein is Quite Low in Japanese Men at High Coronary Risk
- Baseline data of Shizuoka area in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)
- CONTROLS FOR MONITORING THE DETERIORATION OF STORED BLOOD SAMPLES IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)
- Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
- One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma : Case-control study
- Coffee consumption and the risk of endometrial cancer : Evidence from a case-control study of female hormone-related cancers in Japan
- Active Smoking, Passive Smoking, and Breast Cancer Risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
- Dietary intakes of fat and fatty acids and risk of breast cancer : A prospective study in Japan
- Cigarette smoking and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort study
- Impact of menstrual and reproductive factors on breast cancer risk in Japan : Results of the JACC study
- A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women : Findings from the JACC study
- A prospective study on the possible association between having children and colon cancer risk : Findings from the JACC Study
- Smoking and Colorectal Cancer in a Non-Western Population : a Prospective Cohort Study in Japan
- Estimated Number of Patients with Chronic Renal Failure but not with End-Stage Renal Disease in Japan : Comparisons Between Two Estimation Methods
- Predialysis Serum Albumin Concentration and Creatinine Generation Rate Do Not Reflect the Same Pathophysiologic Status
- Foods and beverages in relation to urothelial cancer : Case-control study in Japan
- Association of menstrual and reproductive factors with pancreatic cancer risk in women : findings of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
- Overview of the Epidemiology of Pancreatic Cancer Focusing on the JACC Study
- Overview of Epidemiology of Bile Duct and Gallbladder Cancer Focusing on the JACC Study
- Validity and Reliability of Single-item Questions about Physical Activity
- Estimated Prevalence and Incidence of Adult Still's Disease : Findings by a Nationwide Epidemiological Survey in Japan
- Case-Control Study of Oral Cancer in Shenyang, Northeastern China
- Significance of Urinalysis for Subsequent Kidney and Urinary Tract Disorders in Mass Screening of Adults
- Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men
- Similar and Dissimilar Findings in Japan-Indonesia Case-Control Study on Breast Cancer : Two Phases Study
- Nutritional factors and risk of pancreatic cancer : a population-based case-control study based on direct interview in Japan
- Cigarette Smoking as a Risk Factor for Chronic Pancreatitis : A Case-Control Study in Japan
- Nationwide epidemiological survey of chronic pancreatitis in Japan
- Sleep Patterns and Total Mortality : A 12-Year Follow-up Study in Japan
- A Study on How a 6-Month Aerobic Exercise Program Can Modify Coronary Risk Factors Depending on Their Severity in Middle-Aged Sedentary Women
- Newly Developed Diabetic Retinopathy and Its Preceding Changes in Biological Markers
- Estimated Prevalence of Sjogren's Syndrome in Japan : Findings from a Nationwide Epidemiological Survey
- Reproducibility and Validity of a Simple Checklist-type Questionnaire for Food Intake and Dietary Behavior
- A Case-Control Study Exploring the Role of Serum Manganese Superoxide Dismutase (MnSOD) Levels in Gastric Cancer
- Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk : a Case-Control Study
- Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project : A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
- Written Informed Consent for Participation in a Study and Reduction in Consent Rate
- Serum Insulin-like Growth Factors, Insulin-like Growth Factor-biding Protein-3, and Risk of Lung Cancer Death : A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study
- Smoking Habits, Local Brand Cigarettes and Lung Cancer Risk in Okinawa, Japan
- Out-of-Hospital Cardiac Arrest and Survival : An Epidemiological Analysis of Emergency Service Reports in a Large City in Japan
- Maternal Active and Passive Smoking and Fetal Growth : A Prospective Study in Nagoya, Japan
- A Simple Food Frequency Questionnaire for Japanese Diet : Part II. Reproducibility and Validity for Nutrient Intakes
- A Simple Food Frequency Questionnaire for Japanese Diet : Part I. Development of the Questionnaire, and Reproducibility and Validity for Food Groups
- Descriptive Epidemiology of Pancreatic Cancer in Japan
- Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
- Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project: A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
- Agreement Between Self- and Partner Reports Obtained by a Self-Administered Questionnaire : Medical and Lifestyle Information
- Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus
- Serum Cholesterol and Cancer Mortality in Japanese Civil Service Workers : Findings from a Nested Case-control Study
- Impact of Smoking and Other Lifestyle Factors on Life Expectancy among Japanese : Findings from the Japan Collaborative Cohort (JACC) Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- Epidemiology of Intractable Diseases in Japan
- Epidemiology of Diseases of Unknown Etiology, Specified as "Intractable Diseases"
- Reproducibility and Validity of a Simple Checklist-type Questionnaire for Food Intake and Dietary Behavior
- Longitudinal Evaluation of Multi-phasic, Odontological and Nutritional Associations in Dentists (LEMONADE Study) : Study Design and Profile of Nationwide Cohort Participants at Baseline
- The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
- Reduced serum vascular endothelial growth factor receptor-2 (sVEGFR-2) and sVEGFR-1 levels in gastric cancer patients
- No association between the frequency of forest walking and blood pressure levels or the prevalence of hypertension in a cross-sectional study of a Japanese population
- Body Mass Index and Mortality From All Causes and Major Causes in Japanese : Results of a Pooled Analysis of 7 Large-Scale Cohort Studies
- An Overview of Genetic Polymorphisms and Pancreatic Cancer Risk in Molecular Epidemiologic Studies
- Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors : A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
- Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese-a cross-sectional data from the J-MICC Study
- Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression
- Body Mass Index and Weight Change During Adulthood Are Associated With Increased Mortality From Liver Cancer: The JACC Study
- Obesity/Weight Gain and Breast Cancer Risk: Findings From the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk
- Risk Factors for Breast Cancer among Japanese Women in Tokyo : A Case-Control Study
- O-33 The Associations of Oral Health-related Quality of Life with Stress in Japanese Men and Women
- Significant interaction between RETN-420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese : the J-MICC Study
- Obesity/Weight Gain and Breast Cancer Risk : Findings From the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk
- Low Intake of Vegetables and Fruits and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study
- Coffee Consumption and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study
- Body Mass Index and Weight Change During Adulthood Are Associated With Increased Mortality From Liver Cancer : The JACC Study