Physiological Levels of Estradiol Correlate with Lipid/Lipoprotein Profiles in Healthy Men
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概要
- 論文の詳細を見る
In this cross-sectional study, the relationships of the physiological levels of estradiol (E2) and dehydroepiandrosterone-sulfate (DHEA-S) to the lipid and lipoprotein profiles were investigated in 212 apparently healthy men aged from 18 to 59 years old. These subjects were divided into tertiles according to the levels of E2 and DHEA-S, respectively. We performed one-way analysis of variance and analysis of co-variance controlling for age, body mass index, percent body fat, waist to hip ratio, maximal oxygen uptake, alcohol and cigarette consumptions as confounding factors. A lower E2 level was associated with higher concentrations of total cholesterol (TC) and low density lipoprotein cholesterol. A lower DHEA-S level was associated with a lower concentration of high density lipoprotein cholesterol (HDLC) and a higher ratio of TC/HDLC. These correlations remained significant after adjusting for the above confounding factors. Neither free testosterone nor sex hormone-binding globulin was associated with the lipids and lipoproteins. These results suggest that higher levels of E2 and DHEA-S, at least in physiological concentrations, are related to the favorable lipid and lipoprotein levels in men.
- 日本衛生学会の論文
著者
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Higaki Yasuki
Department of Preventive Medicine, Faculty of Medicine, Saga University
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MORI Mitsuru
Department of Public Health, Sapporo Medical University School of Medicine
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Mori Mitsuru
札幌医科大学 医学部公衆衛生学
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Mori Mitsuru
札幌医科大学 泌尿器科
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Shono Naoko
Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine
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Mori M
Sapporo Medical Univ. School Of Medicine Hokkaido Jpn
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Mori M
Department Of Epidemiology Sapporo Medical University School Of Medicine
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NISHIZUMI Masahiro
Department of Community Health Science, Saga Medical School
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Mori Mitsuru
Department Of Community Health Science Saga Medical School
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Hasegawa Yasuhisa
Division Of Head And Neck Surgery Aichi Cancer Center Hospital
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Shono N
Department Of Community Health Science Saga Medical School
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Higaki Y
Department Of Preventive Medicine Saga Medical School
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Higaki Yasuki
Department Of Preventive Medicine Faculty Of Medicine Saga University
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Higaki Yasuki
Department Of Community Health Science Saga Medical School
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Nishizumi M
Department Of Community Health Science Saga Medical School
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Higaki Yasuki
Laboratory Of Exercise Physiology Faculty Of Sports And Health Science Fukuoka University
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