hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese
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概要
- 論文の詳細を見る
BACKGROUND: The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).METHODS: We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.RESULTS: Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).CONCLUTIONS: These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.J Epidemiol 2006; 16 :233-239.
- 日本疫学会の論文
- 2006-11-01
著者
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Hara Megumi
Department of Preventive Medicine, Faculty of Medicine, Saga University
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Higaki Yasuki
Department of Preventive Medicine, Faculty of Medicine, Saga University
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Horita Mikako
Department of Preventive Medicine, Faculty of Medicine, Saga University
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Tanaka Keitaro
Department of Preventive Medicine, Faculty of Medicine, Saga University
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MIZUTA Toshihiko
Department of Internal Medicine, Saga Medical School
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YASUTAKE Tsutomu
Department of Internal Medicine, Saga University
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Mizuta Toshihiko
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Mizuta Toshihiko
久留米大学 医学部小児科学
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Kono S
Department Of Preventive Medicine Graduate School Of Medical Sciences Kyushu University
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Kadowaki Takashi
滋賀大学 医学部健康科学科
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Koizumi Shunzo
Department of General Medicine, Saga University Faculty of Medicine
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Eguchi Yuichiro
Department of General Medicine, Saga Medical School, Japan
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Koizumi Shunzo
Department Of General Medicine Faculty Of Medicine Saga University
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Hara Megumi
Department Of Community Health Science Saga Medical School
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Horita Mikako
Department Of Preventive Medicine Faculty Of Medicine Saga University
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Tanaka Keitaro
Department Of Preventive Medicine Faculty Of Medicine Saga University
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Tanaka Keitaro
Department Of General And Gastroenterological Surgery Osaka Medical College
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Yamamoto Kyosuke
Department Of Internal Medicine Saga Medical School
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Yamamoto Kyosuke
Department Of Internal Medicine Faculty Of Medicine Saga University
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Yamamoto Kyosuke
Department Of Applied Biological Sciences Saga University
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Takagi Kenzo
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
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Mizuta Toshihiko
Department Of Internal Medicine Saga Medical School
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Yasutake Tsutomu
Department Of Internal Medicine Faculty Of Medicine Saga University
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Sakai Takahiro
Department Of Preventive Medicine Faculty Of Medicine Saga University
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Sakamoto Tatsuhiko
Fukuoka Prefectural Government Asakura Health Welfare Environment Office
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Shigematsu Hirohisa
Department Of Internal Medicine Saga Prefectural Hospital Koseikan
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Kawai Sayo
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Ozaki Iwata
Department Of Internal Medicine Faculty Of Medicine Saga University
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Kawazoe Seiji
Department Of Internal Medicine Saga Prefectural Hospital Koseikan
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Senga Takeshi
Division Of Cancer Biology Nagoya University Graduate School Of Medicine
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Higaki Y
Department Of Preventive Medicine Saga Medical School
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Higaki Yasuki
Department Of Preventive Medicine Faculty Of Medicine Saga University
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Higaki Yasuki
Department Of Community Health Science Saga Medical School
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Yoshimura T
Osaka Univ. Osaka
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ICHIBA Masayoshi
Department of Community Helth Science, Saga Medical College
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Sakai Takahiro
Fukuoka Prefectural Government Asakura Health Welfare Environment Office
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Eguchi Yuichiro
Department Of Internal Medicine Saga Medical School
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Suchi Taizan
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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SAKAMOTO Tatsuhiko
Department of Preventive Medicine, Faculty of Medicine, Saga University
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ONOHARA Shingo
Department of Internal Medicine, Saga Prefectural Hospital Koseikan
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Suzuki Takeshi
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Kadowaki Sayaka
Department Of Health Science Shiga University Of Medical Science
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Onohara Shingo
Department Of Internal Medicine Saga Prefectural Hospital
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Onohara Shingo
Department Of Internal Medicine Saga Prefectural Hospital Koseikan
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Mizuta Toshihiko
Department Of Internal Medicine Faculty Of Medicine Saga University
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Ichiba Masayoshi
Department Of Social And Environmental Medicine Faculty Of Medicine Saga University
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Ichiba Masayoshi
Department Of Community Helth Science Saga Medical College
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Koizumi Shunzo
Department Of Abdominal Surgery Tenri Hospital
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Kawazoe Seiji
Department Of Hepatology Saga Prefectural Hospital
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Sakai Takahiro
Asakura Health Welfare Environment Office Fukuoka Prefectural Government
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Higaki Yasuki
Laboratory Of Exercise Physiology Faculty Of Sports And Health Science Fukuoka University
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Eguchi Yuichiro
Department Of General Medicine Saga Medical School
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Suchi Taizan
Asakura Health Welfare Environment Office Fukuoka Prefectural Government
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KAWAZOE Seiji
Department of Hepato-Biliary-Pancreatology, Saga Prefectural Hospital Koseikan
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Ichiba Masayoshi
Department of Community Health Science, Saga Medical School
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