The Relationship of Insulin Sensitivity to Abdominal Fat Accumulation, Sex Hormones, and Sex Hormone-Binding Globulin in Japanese Men with Impaired Glucose Tolerance

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概要

• 論文の詳細を見る

• 本研究の目的は,耐糖能境界型(IGT)男性の性ホルモン,性ホルモン結合グロプリン(SHBG)及びインスリン感受性の水準を比較検討すると共にインスリン感受性と性ホルモン及びSHBGとの関連性を明らかにすることである。Hyperinsulinemic euglycemic Clamp法で評価したインスリン感受性(glucose infusion rate;GIR), CTスキャン法で評価された腹部の皮下(SFA)・内臓脂肪蓄積(VFA), 性ホルモン(遊離テストステロン, エストラディオール, dehydroepiandrosterone-sulfate)及びSHBG水準が, やせ型から肥満者を含む31-75歳の日本人男性IGT(n=29)を対象に測定された。性ホルモンの分布は, すでに著者らが報告した健常男性で観察された数値の範囲内にあった。しかしながら, 統計処理は行っていないが, SHBG水準は健常者よりも低い傾向にあった。GIRに関しては, IGT男性の約50%が正常範囲内にあった。単相関分析において, GIRは年令やSHBGとの間に有意な正相関を, 一方肥満尺度, 特に腹部の皮下脂肪面積(SFA)との間に有意な負の相関を認めた。ステップワイズ重回帰分析の結果, SFAと75gの経口糖負荷試験(OGTT)に伴うインスリンの曲線下面積は, GIRに関する有意な独立因子であった。さらに, SHBGや遊離テストステロンは, OGTTに伴うインスリン反応と有意な負の相関を認めたが, 腹部のSFA及びVFAの影響を考慮した偏相関分析の結果, 両者の間には有意な関連性は認められなかった。これらの成績から, 腹部の皮下脂肪蓄積や経口糖負荷後の高インスリン反応は, 日本人IGT男性の末梢インスリン感受性の独立因子であることが示唆された。

• 1998-03-16

著者

• Higaki Yasuki

  Department of Preventive Medicine, Faculty of Medicine, Saga University

• Kumagai Shuzo

  Kyushu University

• KUMAGAI Shuzo

  Institute of Health Science, Kyushu University

• Higaki Yasuki

  Department Of Community Health Science Saga Medical School

• Kumagai Shuzo

  Institute Of Health Science Kyushu University

• GOTO Takashi

  Third Department of Internal Medicine, Hirosaki University School of Medicine

• Goto Takashi

  Third Department Of Internal Medicine Hirosaki University School Of Medicine

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