Risk of Death due to Hepatocellular Carcinoma among Drinkers and Ex-drinkers. Univariate Analysis of JACC Study Data
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概要
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Hazard ratios (HR) of death due to hepatocellular carcinoma (HOC) were analyzed by gender and age strata (40-59 and 60-79) among drinkers and ex-drinkers in 66, 974 eligible subjects from a a large cohort of male and female subjects aged 40-79 years, based on information about several drinking related characteristics. The HR of dying from HOC for ex-drinkers was 4 to 8 times higher than for those who had never consumed alcohol at the baseline survey. When the subjects were restricted to those without history of liver disease (LD), the HR was still high for ex-drinkers among younger males, though the difference was not statistically significant. It appeared that the earlier drinking habits were established, the higher the HR, especially for younger males without LD. Among total current drinkers, the amount ingested per occasion and the cumulative amount ingested at the baseline did not show significantly increased HRs. Among subjects without LD, larger amounts ingested per occasion and larger cumulative amount seemed to have higher HRs in older male current drinkers. Frequent drinking and later age (50 to 79) at cessation of drinking were associated with higher HRs among both genders and both age strata. After restricting the analysis to subjects without LD, many of these increased HRs remained among males. The results suggested that the association between alcohol drinking history and HR of HOC differs depending on the presence of LD. Major confounders other than age and gender associated with both drinking and HCC, e.g. smoking, hepatitis virus infection, or history of diabetes, were not considered in this analysis, and the observed associations might be confounded by any of these factors. To clarify the net association between alcohol drinking and HOC, further analysis is needed to control potential confounders, including past history of liver disease, and to consider probable effect modifiers.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Ogimoto Itsuro
Department Of Clinical Epidemiology Institute Of Industrial Ecological Science University Of Occupat
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NOSE Takayuki
Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine,
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Tamakoshi Akiko
Department Of Clinical Trials National Center For Geriatrics And Gerontology
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Kurozawa Youichi
Division Of Health Administration And Promotion Department Of Social Medicine Faculty Of Medicine To
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Fujita Yuki
Department Of Chemistry And Biochemistry Graduate School Of Engineering Kyushu University
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Ichikawa Shoko
Department Of Applied Chemistry Tokyo University Of Science Yamaguchi
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Sakata Ritsu
Department Of Epidemiology Radiation Effects Research Foundation
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Shibata Akira
Department 1st Internal Medicine, Niigata University School of Medicine
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FUKUDA KATSUHIRO
Department of Community Medicine, School of Clinical Medicine, University of Cambridge
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Yoshimura Takesumi
Department of Clinical Epidemiology
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IWAIT NOBUO
Chugoku Occupational Health Association
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