Genotype-Phenotype Agreement of Aldehyde Dehydrogenase 2 in 120 Healthy Japanese.
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概要
- 論文の詳細を見る
An individual genotype of aldehyde dehydrogenase 2 was observed using nail clippings by an improved method consisting of DNA extraction with guanidium thiocyanate, genomic DNA amplification by nonisotopic polymerase chain reaction, and gel electrophoresis of the DNA fragment. The results were consistent with those obtained using the corresponding peripheral blood samples. The individual phenotype was also determined by the Tokyo-University ALDH2-Phenotype Screening Test. Both types of ALDH2 were observed in 120 healthy Japanese and 48% were the typical or normal homozygote, 43% were the heterozygote, and 9% were the atypical or mutant homozygote of ALDH2. Among 57 individuals of both sexes with the typical homozygote, 88% were the phenotype of a non-flusher. Similarly 76% of the 63 heterozygote/atypical homozygotes had the phenotype of a flusher.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kato Hirohisa
Pediatrics And Child Health Kurume University School Of Medicine
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Nishiyori Atsushi
Department Of Pediatrics And Child Health Kurume University School Of Medicine
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FUKUDA KATSUHIRO
Department of Community Medicine, School of Clinical Medicine, University of Cambridge
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ITOH KYOGO
Immunology Kurume University School of Medicine
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