Superoxide Anion Radical (O2-) Generation by Adriamycin and Anthraquinone Analogues.
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概要
- 論文の詳細を見る
The reduction of ferricytochrome c with adriamycin in phospate buffered saline (pH 7.4) and alkaline solution was obsereved spectrophoto-metrically. The reduction increased gradually with time of incubation, and decreased with the addition of superoxide dismutase. The semiquinone radical derived from adriamycin was detected by electron spin resonance spectrometer. Superoxide production by analogous compounds of adriamycin was examined. The cytotoxicity caused by anthraquinone antibiotics is discussed on the basis of molecular structure.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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CHINAMI MASANOBU
Department of Gynecology and Obstetrics, Kurume University, School of Nedicine
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OKAMOTO KUOJI
Radioisotope Institute ofr Basic and Clinical Medicine Kurume University, School of Medicine
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OGURA RYOHEI
Radioisotope Institute ofr Basic and Clinical Medicine Kurume University, School of Medicine
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