STUDIES ON EXPERIMENTAL FORMATION OF OVARIAN TUMORS:ESPECIALLY, THE DISCUSSION OF THE DEVELOPING PROCESS OF OVARIAN TUMORS FOLLOWING AN APPLICATION OF DMBA
スポンサーリンク
概要
- 論文の詳細を見る
The histogenetic process of experimental ovarian tumors induced by a chemically carcinogenic substance, 9, 10-dimethyl-1, 2-benzanthracene (DMBA) in rats was studied. Morphologically, the induced tumors can be classified into two groups : Adenocarcinoma and sarcoma. A particular pattern of histogenetic process in these tumors was evidenced by killing and following these animals at staged intervals from the initiation of the experiment. When treated with DMBA, an inflammatory change occurred around the region of a silk thread insertion; and subsequently, connective tissues proliferated. In the following stages, a layer of epithelial cells which constitutes glandular cysts of various sizes, on one hand and interstitial connective tissue on the other, proliferated around them, presenting the findings of fibroadenoma. This fibroadenoma provided a basic type from which two different histogenetic processes bifurcated. In one direction, cystic components dominated and proceeded toward adenocarcinoma, and in the other connective tissue proliferation prevailed to form a sarcoma type. Between the two of them, the process toward adenocarcinoma is of much interest because of its incidence clinically; and it was found that inclusion cysts appeared to play an important role in the developmental process, which should be of special interest when compared with various reports on the histogenesis of human adenocarcinoma.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Tsunawaki Akitsu
Department Of Obstetrice And Gynecology Kurume University School Of Medicine
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Abe Masakatsu
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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HIROSE Nobuyuki
Department of Informatics, Faculty of Information Science and Electrical Engineering, Kyushu University
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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HIROSE NOBUYUKI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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IDE KAIKITSU
Department of Obste tries and Gynecology, Kurume University School of Medicine
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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ARAKI SUMIO
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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