A PRELIMINARY STUDY OF A COMBINATION CHEMOTHERAPY WITH IFOSFAMIDE, ADRIAMYCIN AND CISPLATIN FOR ENDOMETRIAL CARCINOMA
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概要
- 論文の詳細を見る
子宮内膜腺癌患者7名に対しifosfamide 1g/m^2 ( 5日間) とadriamycin 50 mg/m^2, cisplatin 50 mg/m^2 (各第1日目のみ) から成る術後化学療法 (IAP) を行った。筋層内浸潤を欠く1例では3コース, 他の6名は5コースの治療を受けた。測定可能病変を持つ4例の奏効率はCR3, PR1と, 少数例ながらtotalで100%を示した。PRに留まった1例は以前に放射線による子宮頚癌療法を受けており, その組織型は悪性度が高いとされるpapillary serous adenocarcinomaであった。6例では予定の治療コース終了後second look operationを受け, 組織学的にもno evidence of diseaseが確認された。しかし, このうち1例ではsecond look operation後7カ月で再発が確認された。患者の87%に出現したgrade 4の白血球減少を含む, 本治療の副作用は著明であった。しかしこの血液学的毒性は治療後3週間目には自然回復した。中枢神経障害を含む他の副作用は制御可能であり容認できるものであった。以上の結果よりこのIAP療法は子宮内膜腺癌患者の治療を行う上で有用であると考えられた。
- 社団法人日本産科婦人科学会の論文
- 1988-12-01
著者
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Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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MATSUMURA Takashi
Department of Mechanical Engineering; Tokyo Denki University
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IMAISHI Kiyohisa
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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KISHI Nobuhiro
Department of Obstetrics and Gynecology Kurume University School of Medicine
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Imaishi Kiyohisa
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Kishi Nobuhiro
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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西田 敬
Department of Obstetrics and Gynecology, National Kokura Hospital
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NAGASUE Naoki
Department of Obstetrics and Gynecology, National Kokura Hospital
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Nagasue Naoki
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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Nagasue Naoki
Department Of Obstetrics And Gynecology National Kokura Hospital
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TATENO Nobumasa
Department of Obstetrics and Gynecology, School of Medicine, Kurume University
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Matsumura Takashi
Department Of Mechanical Engineering & Intelligent Systems University Of Electro-communications
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Tateno Nobumasa
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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Tateno Nobumasa
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Matsumura Takashi
Department Of Electronic Engineering Faculty Of Engineering Gunma University
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Matsumura Takashi
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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Imaishi Kiyohisa
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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