GnRH Agonist Acts as Ovarian Protection in Chemotherapy Induced Gonadotoxicity: An Experiment Using a Rat Model
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概要
- 論文の詳細を見る
To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 μg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest section of the ovary on the 5th and 10th day after administration. Leuplin led the ovary to a resting phase in which primordial follicle occupied 80% of all follicles in only 5 days after administration. The serum E2 level was also down by the 5th day and maintained a low level to the 10th day. In co-treatment with GnRHa and CDDP rats, the primordial follicle occupied 90% of all follicles and the total number of follicles was higher than in CDDP alone rats. This rat model verified that GnRHa co-treatment well minimized CDDP induced gonadotoxocity by desensitization of the ovary. These results were promising for the clinical application introducing GnRHa co-treatment as ovarian protection in cancer chemotherapy in young women.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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USHIJIMA Kimio
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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KAMURA Toshiharu
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Matsuo Go
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Ushijima Kimio
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Fukui Akimasa
Department Of Life Science (biology) The University Of Tokyo
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FUJIYOSHI Naoki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Kamura Toshiharu
Department Obstetrics And Gynecology Kurume University School Of Medicine
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Fujiyoshi Naoki
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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TERADA Atsumu
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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SHINAGAWA ATSUHIKO
Shinagawa Hospital
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TAKAHASHI SYUN-ICHI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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TAKEMOTO SYUJI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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USHIJIMA KIMIO
Department of Gynecology, Kurume University School of Medicine
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- GnRH Agonist Acts as Ovarian Protection in Chemotherapy Induced Gonadotoxicity: An Experiment Using a Rat Model