Degenerative Changes in the Serotonergic Fibers in the Spinal Cord of Zitter Mutant Rat
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概要
- 論文の詳細を見る
The morphological features and distribution of serotonergic fibers in the spinal cord of 7-and 12-month-old zitter mutant rats which are characterized by abnormal metabolism of superoxides were examined immunohistochemically. In the zitter rat spinal cord, several aberrant serotonergic fibers characterized by swollen varicosities were intermingled with normal serotonergic fibers. These aberrant fibers increased in number by aging. Serotonergic neuron system seem to be vulnerable to superoxide radicals. Thus, these aberrant serotonergic fibers may reflect the degeneration by superoxide radicals. These aberrant fibers were never found in young adult or 12-month-old SD rats. The appearance of these fibers has been reported in the aged (30 months) rat spinal cord. Based on the morphological similarity, the present study indicates the early onset of age-related change in serotonergic fibers in the spinal cord of zitter rats.
- 日本組織細胞化学会の論文
- 1996-06-01
著者
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Ueda Satoshi
Division Of Pathology Osaka Saiseikai Nakatsu Hospital
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Ueda S
Dokkyo Univ. School Of Medicine Tochigi
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Yamaoka Sadao
Physiology Dokkyo University School Of Medicine
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Kitajima Toshimitsu
Department of Anesthesiology, Dokkyo University School of Medicine
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Ueda Shuichi
Department Of Histology And Neurobiology Dokkyo Medical University School Of Medicine
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Saitoh Yuuki
Department of Anesthesiology, Dokkyo University School of Medicine
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Ueda Shuichi
Histology and Neurobiology, Dokkyo University School of Medicine
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Saitoh Yuuki
Department Of Anesthesiology Dokkyo University School Of Medicine
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Kitajima Toshimitsu
Department Of Anesthesiology Dokkyo University School Of Medicine
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Kitajima Toshimitsu
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Kitajima Toshimitsu
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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