Differences In Duration and Magnitude of Vasodilative Effect by Sympathetic Block with Ropivacaine 0.2 % and Mepivacaine 0.5 % in Dogs

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To clarify differences in the duration and magnitude of vasodilative effect induced by sympathetic block with ropivacaine and mepivacaine. We measured mean arterial pressure (MAP), heart rate (HR), and right and left brachial artery blood flow (BABF) before and after stellate ganglion block (SGB) used as sympathetic block in twelve dogs. The experimental protocol was designed as follows : (1) left SGB using 0.2% ropivacaine 1.0 mL (n=6) and left SGB using 0.5 % mepivacaine 1 mL (n=6). MAP and HR did not change significantly through-out the study in either group. Left SGB with ropivacaine increased left BABF significantly from 5 min through 80 min after SGB (baseline, 100% ; peak at 10 min after SGB, 257±39% ; P<0.01). Left SGB with mepivacaine increased left BABF significantly from 5 min through 50 min after SGB (baseline, 100% ; peak at 10 min after SGB, 183±31% ; P<0.01). The values of left BABF after SGB with ropivacaine were significantly higher than those of SGB with mepivacaine from 5 min through 80 min after the block. Right BABF after left SGB decreased in both groups. Sympathetic block with 0.2% ropivacaine induces significant increases in both duration and magnitude of action in the peripheral blood flow compared with that of 0.5% mepivacaine.
2005-03-25