Comparison of Remifentanil and Landiolol on Hemodynamic and Plasma Catecholamine Responses to Tracheal Intubation
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概要
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The purpose of this study is to compare remifentanil with landiolol to examine the effects of hemodynamicand plasma catecholamine responses to tracheal intubation. Sixty patients scheduled for elective surgerywere randomly divided into three groups, to receive either normal saline( group C), a 1-minute loading infusionof remifentanil 0.5 m g/kg followed by an infusion of remifentanil 0.25/m g/kg/min during the study(group R), or a 1-minute loading infusion of landiolol 0.125 mg/kg followed by an infusion of landiolol0.04 mg/kg/min during the study (group L). After the 1-minute loading infusion of each drug, anesthesiawas induced with intravenous injection of propofol 2 mg/kg, and vecuronium 0.1 mg/kg. Five minutes afterthe administration of each drug, tracheal intubation was performed within 30 seconds. Mean arterial pressureremained below the baseline value after tracheal intubation in group R, but not in groups L and C.Heart rate significantly increased after tracheal intubation in group C, but not in groups R and L. Plasmaconcentration of adrenaline remained below the baseline value after tracheal intubation in all groups, but itwas significantly lower in group R, compared with other groups. Plasma concentration of noradrenaline significantlyincreased after tracheal intubation in groups L and C, but not in group R. Bispectral index ingroup R remained lower than that in groups L and C after tracheal intubation. Remifentanil may be preferableto landiolol to provide cardiovascular stability after tracheal intubation.
- 2012-03-25
著者
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Yamaguchi Shigeki
Department Of Anesthesiology Dokkyo Medical University
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Shigeki Yamaguchi
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Kazuyoshi Ishikawa
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Kenshu Shirakawa
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Masaru Nagao
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Masaru Nagao
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Kenshu Shirakawa
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Nagao Masaru
Department Of Anesthesiology Dokkyo Medical University School Of Medicine
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Shirakawa Kenshu
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Nagao Masaru
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Ichikawa Kazuyoshi
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Nagao Masaru
Department Of Anesthesia And Pain Medicine, Dokkyo Medical University School Of Medicine
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