Low Dose Landiolol Combined with Catecholamine Can Decrease Heart Rate without Suppression of Cardiac Contraction after Cardiopulmonary Bypass

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Objective:Landiolol is a new ultra-short acting beta-adrenergic blocker that has potential for use in perioperative hemodynamic stabilization. The purpose of this study was to examine the effect of combined administration of landiolol and Catecholamine on regulation of heart rate in tachycardia after cardiopulmonary bypass.Design:The study was performed as a prospective controlled trial. Setting:A university hospital.Participants:The subjects were 30 of 64 patients with heart rate ≧ 115 bpm after weaning from cardiopulmonary bypass.Interventions:Fifteen of the patients (the landiolol group) were administered landiolol at a dose of 3-5 mg/kg/min without a decrease in the dose of Catecholamine. The other 15 patients( the control group)did not receive landiolol, but the Catecholamine dose of 1 m g/kg/min was decreased to reduce the heart rate.Results:Mean arterial pressure, cardiac index and heart rate were measured 5, 10 and 15 min after drug administration and postoperatively. Mean arterial pressure and cardiac index were unchanged after drug administration, but heart rate was significantly lower after 15 min and postoperatively in patients administered landiolol compared with those who did not receive landiolol. Conclusions:Combined administration of landiolol and Catecholamine is useful for stabilization of cardiovascular changes after cardiopulmonary bypass surgery.
獨協医科大学の論文
2014-03-25