Comparison of Sympathetic Block with 2.0% Mepivacaine and Surgical Sympathectomy with Radiofrequency Thermocoagulation on Vasodilative Effect in Dogs
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概要
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The aim of this study is to compare sympathetic block using 2.0% mepivacaine with surgical sympathectomy using radio frequency thermocoagulation for the duration and magnitude of the vasodilative effect. Mean arterial pressure (MAP), heart rate (HR), and right and left brachial artery blood flow (BABF) were measured before and after left cervicothracic sympathetic block using 2.0% mepivacaine or surgical sympathectomy in dogs. The experimental protocol was designed as follows : (1) left cervicothoracic sympathetic block using 1.0ml of 2.0% mepivacaine (n=8), and surgical sympathectomy using radiofrequency thermocoagulation (n=8). MAP and HR did not change significantly throughout the study in both groups. Left cervicothracic sympathetic block increased left BABF significantly from 5 min through 80 min after cervicothracic sympathetic block (baseline, 100% ; peak at 10 min after the block, 186±40% ; P<0.01). Left surgical sympathectomy increased left BABF significantly from 5 min through 120 min after the sympathectomy (baseline 100% ; peak at 60min after the sympathectomy, 265±59% ; P<0.01). Left BABF in surgical sympathectomy was significantly higher than those in cervicothoracic sympathetic block throughout the study. The values of right BABF decreased significantly compared with the baseline value throughout the study in both groups. In conclusion left cervicothracic sympathetic block using 2.0 % mepivacaine induces less duration and magnitude of the vasodilative effect compared with surgical sympathectomy with radiofrequency thermocoagulation.
著者
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Takahashi Yoshiyuki
Departments of Pediatric Cardiology and Surgery, The Heart Institute, Tokyo Women's Medical College
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Hamaguchi Shinsuke
Department Of Anesthesiology Dokkyo Medical University
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YAMAGUCHI Shigeki
Department of Mechanical Engineering, Nagoya Institute of Technology
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Kimura Yoshiyuki
Department Of Anesthesiology Dokkyo Medical University
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Shinozaki Mio
Department of Anesthesiology, Dokkyo Medical University
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Iwasaki Tadaomi
Department of Anesthesiology, Dokkyo Medical University
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Fukagawa Daigo
Department of Anesthesiology, Dokkyo Medical University
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Shinozaki Mio
Department Of Anesthesiology Dokkyo Medical University
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Fukagawa Daigo
Department Of Anesthesiology Dokkyo Medical University
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Iwasaki Tadaomi
Department Of Anesthesiology Dokkyo Medical University
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Takahashi Yoshiyuki
Department Of Anesthesiology Dokkyo Medical University
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Yamaguchi Shigeki
Department Of Anesthesiology Dokkyo Medical University
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Hamaguchi Shinsuke
Department of Anesthesiology, Dokkyo Medical University
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Kimura Yoshiyuki
Department of Anesthesiology, Dokkyo Medical University School of Medicine
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Takahashi Yoshiyuki
Department Of Anesthesia And Pain Medicine, Dokkyo Medical University School Of Medicine
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Hamaguchi Shinsuke
Department Of Anesthesia And Pain Medicine, Dokkyo Medical University School Of Medicine
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