Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo : — Cross Adaptation —
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概要
- 論文の詳細を見る
The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo. Here we briefly review the radioadaptive response with respect to mutagenesis, survival rate, and carcinogenesis in vivo, and introduce our recent findings of cross adaptation in mouse thymic cells, that is, the suppressive effect of repeated low-dose radiation on mutation induction by the alkylating agent N-ethyl-N-nitrosourea.Translated and modified from Radiat. Biol. Res. Comm. Vol.43(4); 436-442, (2008, in Japanese)
- 日本放射線影響学会の論文
著者
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Kakinuma Shizuko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Shimada Yoshiya
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Kakinuma Shizuko
放射線医学総合研究所 発達期被ばく影響研究グループ
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NISHIMURA Mayumi
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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YAMAUCHI Kazumi
Experimental Biology for Children's Health Research Group, National Institute of Radiological Scienc
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AMASAKI Yoshiko
Experimental Biology for Children's Health Research Group, National Institute of Radiological Scienc
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Amasaki Yoshiko
Experimental Biology For Children's Health Research Group National Institute Of Radiological Sc
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Shimada Yoshiya
Experimental Radiobiology For Children's Health Res. Group Res. Center For Radiation Protection
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Nishimura Mayumi
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Yamauchi Kazumi
Experimental Biology For Children's Health Research Group National Institute Of Radiological Sc
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SHIMADA Yoshiya
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
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NISHIMURA Mayumi
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
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KAKINUMA Shizuko
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
関連論文
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- 53 Strain-dependent mammary carcinogenicity of heavy ions in the rat(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Genetic Susceptibility to Thymic Lymphomas and K-Ras Mutation in Mice after Exposure to X-rays and N-Ethyl-N-Nitrosourea
- Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice
- Differences of Molecular Alteration between Radiation-Induced and N-Ethyl-N-Nitrosourea-Induced ThymicLymphomas in B6C3F1 Mice.
- Multiple inactivation pathways of Ikaros, a potent tumor suppressor gene, in primary murine T-cell leukemia
- Age-dependent susceptibility to radiation thymic lymphomagenesis
- Diverse spectrum of K-ras mutation and its association with loss of heterozygosity on chromosome 6 in X-ray-induced thymic lymphomas of B6C3F1 mice.
- Point mutation in PU. 1 in radiation-induced mouse myeloidleukemia(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
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- Loss of heterozigosity and Hras mutations in X-ray-induced B6C3F1 mouse liver tumors
- Age dependence of radiation-induced renal cell carcinomas in an Eker rat model
- Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo : Cross Adaptation
- Radiation-Induced Mammary Carcinogenesis in Rodent Models : What's Different from Chemical Carcinogenesis?
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- Combined Effect of Ionizing Radiation and Alkylating Agents on Cancer Induction
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- 49 Combined Effect of X-rays and N-Ethyl-N-Nitrosourea at Threshold Dose on The Induction of Thymic Lymphomas in B6C3F1 Mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
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- 41 Experimental scheme of combined effect of radiation and chemical carcinogens : dose response relationship and molecular mechanism(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 34 Dose-response Relationship of Thymic Lymphoma Induction by Gamma Radiation and Induction of Nonthymic Lymphomas at Very Low Doses in SCID Mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
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- Analysis of Radiation-induced Germline Mutation Using SNP Marker
- Genomi-wide Analysis of the Loss of Heterozygosity in Radiation-induced Thymic Lymphomas of Scid Mice
- Mechanisms of Deletion Formation in Notch1 Gene in Radiation-Induced Mouse Thymic Lymphomas
- Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo : — Cross Adaptation —
- Selection of thymocytes susceprible for interleukins 7 and 9 at preleukemic stage in split-dose irradiated B6C3F1mice.
- P-11. Influence of strain difference on the chromosome abnormality in mouse thymic lymphomas caused by carbon-ion beam(Abstracts for the oral and the poster presentations,Abstracts of the Joint Meeting: the 58th Annual Meeting of the Society of Chromosome
- P-12. Structural abnormalities of chromosomes 11 and 12 in X-ray induced mouse thymic lymphoma(Abstracts of the oral and poster presentations)
- Sequential expression of T-cell growth factor receptors on T-cell subsets in the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
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- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
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- Candidate Signatures of Radiation Carcinogenesis
- Diverse Spectrum of ras Mutations in Radiation-Induced Thymic Lymphomas.
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- Effects of the Genetic Backgrounds on the Radiation Sensitivity and Carcinogenesis of Scid Mouse
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- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
- Expression of cytokine receptors on T-cell subsets during the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
- Altered Expression of Transcription Factors in Thymic Lymphomas Induced by X-rays in B6C3F1 Mice