Combined Effect of Ionizing Radiation and Alkylating Agents on Cancer Induction
スポンサーリンク
概要
- 論文の詳細を見る
Human beings are exposed to numerous natural and man-made agents that are potentially carcinogenic. Therefore, cancer risk by ionizing radiation (IR) should be assessed as a result of combined exposures with other agents. These agents include genotoxic and non-genotoxic chemical carcinogens such as, tobacco, hormones, viruses, metals etc. Carcinogenesis is a multi-step process that accumulates several genetic and epigenetic changes of oncogenes and tumor suppressor genes. For agents having similar biological function and affecting the same step of carcinogenesis, additivity is generally expected, while for agents acting at different rate-limiting step, combined exposure is expected to be deviated from additivity. Conceptually, carcinogens are classified as initiator and promoter. IR could function at several steps as initiator, promoter or both. In order to predict the mode of combined action of IR with other agents, the sequence and time interval of the exposures, the dose, and the type of exposure (acute or chronic) are the critical factors. In this review, we focus on the combined effect of IR and alkylating agents. The data in the literatures and in our laboratory on mouse thymic lymphomas indicate that combined effect of these two genotoxic agents is synergistic, additive or antagonistic, depending on the dose and the sequence. Mechanistic approach determining frequency and spectrum of cancer-related genes and loss of heterozygosity (LOH) shows that role of IR differs in combined exposures depending on the dose. At low dose range, in general, the combined effect may not deviate from additivity. More information on the mode and the mechanism of low-level exposures, which occasionally encountered in environmental and occupational situation, are required for reaching a unifying concept.
- 日本環境変異原学会の論文
- 2007-05-28
著者
-
Kakinuma Shizuko
放射線医学総合研究所放射線防護研究センター 発達期被ばく影響研究グループ
-
Kakinuma Shizuko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
-
Shimada Yoshiya
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
-
Kakinuma Shizuko
放射線医学総合研究所 発達期被ばく影響研究グループ
-
IMAOKA Tatsuhiko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
-
Doi Masahiro
Regulatory Sciences Research Group National Institute Of Radiological Sciences
-
Kawaguchi Isao
Regulatory Sciences Research Group National Institute Of Radiological Sciences
-
YAMAUCHI Kazumi
Experimental Biology for Children's Health Research Group, National Institute of Radiological Scienc
-
IMishimura Mayumi
Experimental Radiobiology for Children's Health Research Group, National Institute of Radiological S
-
Amasaki Yoshiko
Regulatory Sciences Research Group, National Institute of Radiological Sciences
-
Shang Yi
Experimental Radiobiology for Children's Health Research Group, National Institute of Radiological S
-
SHIMADA Yoshiya
National Institute of Radiological Sciences
-
Imaoka Tatsuhiko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
-
Imaoka Tatsuhiko
Department Of Biological Sciences Graduate School Of Science University Of Tokyo:department Of Molec
-
Shang Yi
Experimental Radiobiology For Children's Health Research Group National Institute Of Radiologic
-
Amasaki Yoshiko
Experimental Biology For Children's Health Research Group National Institute Of Radiological Sc
-
Shimada Yoshiya
Experimental Radiobiology For Children's Health Res. Group Res. Center For Radiation Protection
-
Nishimura Mayumi
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
-
Imishimura Mayumi
Experimental Radiobiology For Children's Health Research Group National Institute Of Radiologic
-
Shimada Yoshiya
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
-
Yamauchi Kazumi
Experimental Biology For Children's Health Research Group National Institute Of Radiological Sc
-
SHIMADA Yoshiya
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
-
NISHIMURA Mayumi
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
-
KAKINUMA Shizuko
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
関連論文
- Recent Advances in the Biology of Heavy-Ion Cancer Therapy
- 193 Radiosensitivity of the LEC rat(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 53 Strain-dependent mammary carcinogenicity of heavy ions in the rat(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Genetic Susceptibility to Thymic Lymphomas and K-Ras Mutation in Mice after Exposure to X-rays and N-Ethyl-N-Nitrosourea
- Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice
- Differences of Molecular Alteration between Radiation-Induced and N-Ethyl-N-Nitrosourea-Induced ThymicLymphomas in B6C3F1 Mice.
- Strain Differences and Effects of Scid-gene on the Genomic Instability in Radiation-induced Thymic Lymphomain Mice
- Multiple inactivation pathways of Ikaros, a potent tumor suppressor gene, in primary murine T-cell leukemia
- Age-dependent susceptibility to radiation thymic lymphomagenesis
- Diverse spectrum of K-ras mutation and its association with loss of heterozygosity on chromosome 6 in X-ray-induced thymic lymphomas of B6C3F1 mice.
- Point mutation in PU. 1 in radiation-induced mouse myeloidleukemia(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- 36 Detection of Illegitimate Sites by Intracisternal A-particle-mediated Retrotransposition in Radiation-induced Tumors(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Genome rearrangement mediated by limited subtypes of IAP in myeloid leukemia and thymic lymphoma cells from C3H mouse.
- Altered expression of transcriptional factors in thymic lymphomas induced by X-rays in B6C3F1 mice
- Loss of heterozigosity and Hras mutations in X-ray-induced B6C3F1 mouse liver tumors
- Age dependence of radiation-induced renal cell carcinomas in an Eker rat model
- Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo : Cross Adaptation
- Radiation-Induced Mammary Carcinogenesis in Rodent Models : What's Different from Chemical Carcinogenesis?
- Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas
- Combined Effect of Ionizing Radiation and Alkylating Agents on Cancer Induction
- Evaluation of radiation-induced brain developmental effect by neuronal apoptosis in mouse fetus(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Difference of molecular alteration between radiation-induced and N-ethyl-N-nitrosourea-induced thymic lymphomas in B6C3F1 mice(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Influence of genetic background on RBE of carbon ions for tumor induction
- Effect of carbon ions on life span shortening and tumorigenesis in mice
- 194 Radiation-induced Germ-line Mutations Detected by a Direct Comparison of Parents and Children DNA Sequences Containing SNPs(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 49 Combined Effect of X-rays and N-Ethyl-N-Nitrosourea at Threshold Dose on The Induction of Thymic Lymphomas in B6C3F1 Mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 43 Age dependency of X ray-induced mammary carcinogenesis in Apc^ mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 41 Experimental scheme of combined effect of radiation and chemical carcinogens : dose response relationship and molecular mechanism(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 34 Dose-response Relationship of Thymic Lymphoma Induction by Gamma Radiation and Induction of Nonthymic Lymphomas at Very Low Doses in SCID Mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 16 Molecular detection of mouse germline mutation(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas
- Analysis of Radiation-induced Germline Mutation Using SNP Marker
- Genomi-wide Analysis of the Loss of Heterozygosity in Radiation-induced Thymic Lymphomas of Scid Mice
- Mechanisms of Deletion Formation in Notch1 Gene in Radiation-Induced Mouse Thymic Lymphomas
- Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo : — Cross Adaptation —
- Selection of thymocytes susceprible for interleukins 7 and 9 at preleukemic stage in split-dose irradiated B6C3F1mice.
- P-11. Influence of strain difference on the chromosome abnormality in mouse thymic lymphomas caused by carbon-ion beam(Abstracts for the oral and the poster presentations,Abstracts of the Joint Meeting: the 58th Annual Meeting of the Society of Chromosome
- P-12. Structural abnormalities of chromosomes 11 and 12 in X-ray induced mouse thymic lymphoma(Abstracts of the oral and poster presentations)
- Sequential expression of T-cell growth factor receptors on T-cell subsets in the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
- Fine mapping of LOH region in chromosome 11 and altered expression of Ikaros, Lif, Nf2, Osm and Egfr genes in X-ray-induced B6C3F1 thymic lymphomas
- Molecular analysis of hereditary effects caused by low-dose irradiation
- Cortactin-Binding Protein 90 (CBP90) Expression in the Mouse Mammary Glands during Prolactin-Induced Lobuloalveolar Development
- Extrapituitary Expression of the Prolactin Gene in the Goldfish, African Clawed Frog and Mouse
- EXTRAPITUITARY PROLACTIN EXPRESSION IN THE GOLDFISH, AFRICAN CLAWED FROG, AND MOUSE
- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
- Effects of the Genetic Backgrounds on the Radiation Sensitivity and Carcinogenesis in Scid Mice
- Effects of Scid Mutation on Radiation Carcinogenesis - Modification of Radiation Carcinogenesis by A Genetic Factor -
- Effects of Bone Marrow Transplantation on the Radiation Induceduction of Thymic Lymphomas in Scid Mice
- High Incidence of DNA Rearrangements of Oncogene Notch 1 in Radiation-Induced Thymic Lymphomas of Scid Mice
- Candidate Signatures of Radiation Carcinogenesis
- Diverse Spectrum of ras Mutations in Radiation-Induced Thymic Lymphomas.
- Enhanced expression of IL9 receptor on thymocytes in the development of thymic lymphomas in C.B-17scid/scid mice after X-ray exposure
- Effects of the Genetic Backgrounds on the Radiation Sensitivity and Carcinogenesis of Scid Mouse
- Lifetime risk estimate of breast cancer resulting from ionizing radiation exposure among Japanese women
- Radiation-Induced Mammary Carcinogenesis in Rodent Models: Whats Different from Chemical Carcinogenesis?
- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
- The 1st YRBAJ Seminar : Techniques and Knowledge to Probe Biological Cellular Responses Occurring in a Hypoxic Microenvironment
- Expression of cytokine receptors on T-cell subsets during the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
- Altered Expression of Transcription Factors in Thymic Lymphomas Induced by X-rays in B6C3F1 Mice
- Analysis of Carcinogenic Target Cells in Mouse Thymic Lymphomas Induced by Ionizing Radiation or Chemical Carcinogen