Changes in the Expression Pattern of Luteinizing Hormone Receptor mRNA in Rat Testis during Degeneration of Seminiferous Epitheliun
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概要
- 論文の詳細を見る
Previously we reported that the experimental unilateral crytorchidism altered the expression pattern of LH receptor mRNA in abdominal testis. To clarify whether the change was due to exposure of Leydig cells to high temperature in the abdomen, we examined the effect of unilateral efferent duct ligation on the expression. Two weeks after the operation, a relatively decreased expression of 1.8 kb transcript, increased expression of other transcripts, and degeneration of germ cells were observed in the efferent ductligated testes. As these changes were similar to those seen in abdominal testes of cryotorchid rats, exposure of Leydig cells to high temperature was not responsible for the changes in expression pattern of LH receptor mRNA. To examine the correlation between the changes in the receptor mRNA expression and the degeneration of seminiferous epithelium, expression of the mRNA was analyzed in unilaterally cryptorchid rats for 28 days after the operation. In scrotal testes which showed no histological changes, a major, 1.8 kb and several minor, 6.5, 2.6, 1.4, 1.1 and 0.9 kb, transcipts were detected throughout the experimental period. In abdominal testes, the expression of 1.8 kb transcript declined rapidly within three days, while that of 6.5 kb and 2.6 kb was increased, reaching a maximum 14 days after the operation. Histological observations of crytorchid and efferent duct-ligated testes revealed that these changes in the receptor mRNA expression paralleled the successive disappearance of spermatids and spermatocytes. These results suggest that the changes in expression pattern of LH receptor mRNA are closely related with degeneration of germ cells and that intratesticular paracrine factor(s)from seminiferous tubules might be concerned to the phenomenon.
- 社団法人日本動物学会の論文
著者
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Mori Takao
Department Of Cardiology Miki City Hospital
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Park Min
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Iizuka Akiko
Department Of Biological Sciences Graduate School Of Science University Of Tokyo
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Park Min
Department Of Biological Science Graduate School Of Science The University Of Tokyo
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Mori Takao
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Park Min
Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea
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