Protective Effects of an Extract of Young Radish (Raphanus sativus L) Cultivated with Sulfur (Sulfur-Radish Extract) and of Sulforaphane on Carbon Tetrachloride-Induced Hepatotoxicity
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概要
- 論文の詳細を見る
The protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane, an isothiocyanate, on carbon tetrachloride (CCl4)-induced liver injury were observed in mice. CCl4 produced a marked increase in the serum level of alanine aminotransferase (ALT), primed lipid peroxidation, and resulted in intense necrosis due to oxidative stress. Oral administration of the sulfur-radish extract and of sulforaphane after CCl4-induced liver injury both decreased the serum level of ALT, reduced the necrotic zones, inhibited lipid peroxidation, and induced phase 2 enzymes without affecting cytochrome P450-2E1 (CYP2E1). These results suggest that the administration of the sulfur-radish extract and of sulforaphane may partially prevent CCl4-induced hepatotoxicity, possibly by indirectly acting as an antioxidant by improving the detoxification system.
- 社団法人 日本農芸化学会の論文
著者
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Park Min
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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BAEK Seung-Hae
Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan
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SUH Jae-Hee
Department of Pathology, Ulsan University Hospital
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CHOI Hye-Seon
Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan
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