Synthesis of Oxovanadium Complexes and Their Apoptosis-Inducing Activity in Leukemia Cells
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概要
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Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes—3b and 4—exhibited strong activities with IC50 values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells.
著者
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Yokoyama Akihiro
Department Of Applied Chemistry Kanagawa University
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Watanabe Shinya
Department Of Chemical Engineering Nagoya University
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Yamaguchi Tomoko
Department Of Engineering Science Faculty Of Engineering Hokkaido University
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Yamaguchi Tomoko
Department of Materials and Life Science, Faculty of Science and Technology, Seikei University
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Tokuoka Yoshikazu
Department of Medical Technology, Faculty of Biomedical Engineering, Toin University of Yokohama
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Matsumura Yuriko
Department of Materials and Life Science, Faculty of Science and Technology, Seikei University
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Yokoyama Akihiro
Department of Materials and Life Science, Faculty of Science and Technology, Seikei University
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WATANABE Shinya
Department of Animal Breeding and Reproduction, NARO Institute of Livestock and Grassland Science, Ibaraki 305-0901, Japan
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