Inhibitory Effect of MD-Fraction on Tumor Metastasis : Involvement of NK Cell Activation and Suppression of Intercellular Adhesion Molecule (ICAM)-1 Expression in Lung Vascular Endothelial Cells(Highlighted paper selected by Editor-in-chief,Microbiology)

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概要

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• The anti-metastatic activity of MD-Fraction extracted from the maitake mushroom (Grifola frondosa) was examined in an experimental murine model of lung metastasis. Intraperitoneal administration of MD-Fraction 2d before tumor implantation significantly inhibited lung metastasis of colon-26 carcinoma and B16/BL6 melanoma cells. In this model, MD-Fraction enhanced IL-12 production from antigen presenting cells (APCs). MD-Fraction treatment activated NK cells and increased cytotoxicity against YAC-1 and colon-26 carcinoma cells. Furthermore, the depletion of NK cells with anti-asialo GM1 abolished the inhibitory effect of MD-Fraction on lung metastasis of colon-26 cells. Ex vivo, B16/BL6 cell adhesion to LPS-activated murine lung vascular endothelial cells was inhibited by MD-Fraction and anti-intercellular adhesion molecule (ICAM)-1 antibody. These results suggest that MD-Fraction inhibits tumor metastasis by activating NK cells and APCs, and by suppressing of ICAM-1 leading to the inhibition of tumor cell adhesion to vascular endothelial cells.

• 公益社団法人日本薬学会の論文
• 2008-06-01

著者

• Hayashi Masahiko

  Department of Earth System Science, Faculty of Science, Fukuoka University

• MASUDA Yuki

  Department of Biotechnology, Faculty of Engineering, Kansai University

• Masuda Yuki

  Department Of Microbial Chemistry Kobe Pharmaceutical University

• Masuda Yuki

  Department Of Biotechnology Faculty Of Engineering Kansai University

• NANBA Hiroaki

  Department of Microbial Chemistry, Kobe Pharmaceutical University

• Hayashi Masahiko

  Department Of Earth System Science Faculty Of Science Fukuoka University

• Nanba Hiroaki

  Department Of Microbial Chemistry Kobe Pharmaceutical University

• MURATA Yukihito

  Department of Microbial Chemistry, Kobe Pharmaceutical University

• Nanba Hiroaki

  Kobe Pharmaceutical Univ. Kobe Jpn

• Hayashi Masahiko

  Department Of Chemistry Graduate School Of Science Kobe University

• Hayashi Masahiko

  Department Of Pharmacy Iwaki Meisei University

• Hayashi Masahiko

  Department Of Agricultural Biochemistry And Biotechnology Tottori University

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