A Polysaccharide, Extract From Grifola frondosa, Induces Th-1 Dominant Responses in Carcinoma-Bearing BALB/c Mice
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概要
- 論文の詳細を見る
A polysaccharide, designated as the D-fraction, extracted from maitake (Grifola frondosa), was reported to have anti-tumor effects by activating macrophages and T cells in C3H/HeN mice in which a Th-1 dominant response was established. In this study using BALB/c mice in which a Th-2 response is genetically dominant, D-fraction reduced the expression of Th-2 cytokine interleukin (IL)-4 but markedly increased the expression of Th-1 cytokine interferon (IFN)-γ in CD4+ T cells and also increased IL-12p70 production as well as IFN-γ production by antigen-presenting cells (APCs), suggesting that D-fraction promotes the differentiation into Th-1 cells of CD4+ T cells through enhancement of IL-12p70 production by APCs.
- 社団法人 日本薬理学会の論文
- 2002-12-01
著者
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KODAMA Noriko
Department of Microbial Chemistry, Kobe Pharmaceutical University
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NANBA Hiroaki
Department of Microbial Chemistry, Kobe Pharmaceutical University
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Nanba Hiroaki
Department Of Microbial Chemistry Kobe Pharmaceutical University
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Kodama Noriko
Department Of Basic Educational Center For Pharmacy Kobe Pharmaceutical University
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HARADA Nachi
Department of Microbial Chemistry, Kobe Pharmaceutical University
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Harada N
Department Of Microbial Chemistry Kobe Pharmaceutical University
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Harada Nachi
Department Of Microbial Chemistry Kobe Pharmaceutical University
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- A Polysaccharide, Extract From Grifola frondosa, Induces Th-1 Dominant Responses in Carcinoma-Bearing BALB/c Mice
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