Effect of Maitake (Grifola frondosa) D-Fraction on the Control of the T Lymph Node Th-1/Th-2 Proportion
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概要
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We have already reported that the D-Fraction, a β-glucan extracted from the fruiting body of the maitake mushroom (Grifola frondosa), activates cellular immunity and expresses anti-tumor effects. In this study we investigated the anti-tumor functions of D-Fraction in relation to its control of the balance between T lymphocyte subsets Th-1 and Th-2. D-Fraction decreased the activation of B cells and potentiated the activation of helper T cells, resulting in enhanced cellular immunity. It also induced the production of interferon (IFN)-γ, interleukin (IL)-12 p70, and IL-18 by whole spleen cells and lymph node cells, but suppressed that of IL-4. These results suggest that D-Fraction establishes Th-1 dominance which induces cellular immunity in the population that was Th-2 dominant due to carcinoma.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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INOUE Atsuyuki
Department of Computer Science and Systems Engineering, Faculty of Engineering, Yamaguchi University
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Inoue Atsuyuki
Department Of Computer Science And Systems Engineering Faculty Of Engineering Yamaguchi University
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Inoue Atsuyuki
Department Of Microbial Chemistry Kobe Pharmaceutical University
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KODAMA Noriko
Department of Microbial Chemistry, Kobe Pharmaceutical University
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NANBA Hiroaki
Department of Microbial Chemistry, Kobe Pharmaceutical University
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Nanba Hiroaki
Department Of Microbial Chemistry Kobe Pharmaceutical University
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Kodama Noriko
Department Of Basic Educational Center For Pharmacy Kobe Pharmaceutical University
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Kodama Noriko
Kobe Pharmaceutical Univ. Kobe Jpn
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Nanba Hiroaki
Kobe Pharmaceutical Univ. Kobe Jpn
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