A Missing Link Between a High Salt Intake and Blood Pressure Increase
スポンサーリンク
概要
- 論文の詳細を見る
It is widely accepted that a high sodium intake triggers blood pressure rise. However, only one-third of the normotensive subjects were reported to show salt-sensitivity in their blood pressure. Many factors have been proposed as causes of salt-sensitive hypertension, but none of them provides a satisfactory explanation. We propose, on the basis of accumulated data, that the reduced activity of the kallikrein-kinin system in the kidney may provide this link. Renal kallikrein is secreted by the distal connecting tubular cells and all kallikrein-kinin system components are distributed along the collecting ducts in the distal nephron. Bradykinin generated is immediately destroyed by carboxypeptidase Y-like exopeptidase and neutral endopeptidase, both quite independent from the kininases in plasma, such as angiotensin converting enzyme. The salt-sensitivity of the blood pressure depends largely upon ethnicity and potassium intake. Interestingly, potassium and ATP-sensitive potassium (KATP) channel blockers accelerate renal kallikrein secretion and suppress blood pressure rises in animal hypertension models. Measurement of urinary kallikrein may become necessary in salt-sensitive normotensive and hypertensive subjects. Furthermore, pharmaceutical development of renal kallikrein releasers, such as KATP channel blockers, and renal kininase inhibitors, such as ebelactone B, may lead to the development of novel antihypertensive drugs.
- 社団法人 日本薬理学会の論文
- 2006-05-15
著者
-
Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
-
Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
関連論文
- An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein
- The effects of orange juice and lemon juice on the pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects
- Effect of Erythropoietin on Angiogenesis With the Increased Adhesion of Platelets to the Microvessels in the Hind-Limb Ischemia Model in Mice
- Transient Prevention of Ethanol-Induced Gastric Lesion by Capsaicin Due to Release of Endogenous Calcitonin Gene-Related Peptide in Rats
- Population Pharmacokinetic-Pharmacodynamic Modeling of TF-505 Using Extension of Indirect Response Model by Incorporating a Circadian Rhythm in Healthy Volunteers(Biopharmacy)
- Role of endogenous thromboxane in hepatic microcirculatory dysfunction during endotoxemia in mice
- Coherent-Anomaly Method in Critical Phenomena.III.Mean-Field Transfer-Matrix Method in the 2D Ising Model
- Coherent Anomaly Method in Critical Phenomena.I.
- ROLE OF NEUTROPHIL ELASTASE IN ENDOTOXIN-INDUCED HEPATIC MICROCIRCULATORY DYSFUNCTION IN MICE
- Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis
- Nitric oxide generated by iNOS reduces deformability of Lewis lung carcinoma cells
- Prostanoid receptor in tumor-associated angiogenesis and tumor growth
- Adenylate Cyclase/Protein Kinase A Signaling Pathway Enhances Angiogenesis Through Induction of Vascular Endothelial Growth Factor In Vivo
- Roles of calcitonin gene-related peptide and prostaglandin I_2 in prevention of ethanol-induced gastric mucosal microcirculatory disturbances by mild irritant in rats
- Suppression of Dextran Sulfate Sodium-Induced Colitis in Kininogen-Deficient Rats and Non-peptide B_2 Receptor Antagonist-Treated Rats
- OE-301 Erythropoietin Promotes Angiogenesis by Prompting Platelets to be Adherent to Endothelial Cells in Hindlimb Ischemia in Mice(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scien
- PJ-542 Role of VEGFR1 Tyrosine Kinase Signaling in Enhancement of Angionegesis in Acute Hind limb Ischemia(Molecular biology, vascular(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Cyclooxygenase-2 Inhibitors Attenuate Increased Blood Pressure in Renovascular Hypertensive Models, but Not in Deoxycorticosterone-Salt Hypertension
- Involvement of the Renal Kallikrein-Kinin System in Furosemide-Induced Natriuresis in Rats
- Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats
- Increase in Vascular Sensitivity to Angiotensin II and Norepinephrine after Four - Day Infusion of 0.3M Sodium Chloride in Conscious Kininogen - Deficient Brown Norway Katholiek Rats
- Oxytocin-Induced Natriuresis Mediated by the Renal Kallikrein-Kinin System in Anesthetized Male Rats
- Induction Mechanism of Small Intestinal Lesions Caused by Intravenous Injection of Endotoxin in Rats
- A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats
- A Potential Role of Bradykinin in Angiogenesis and Growth of S-180 Mouse Tumors
- Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiongenesis in Rat Sponge Implants
- Induction of Cyclooxygenase Type - 2(COX - 2) in Rat Endometrium at the Peak of Serum Estradiol during the Estrus Cycle
- Hyperglycemia-induced Alteration in Proteomes of the Rat Renal Cortex
- Study of Coherent Anomalies and Critical Exponents Based on High-Level Cluster-Variation Approximations
- RELIABLE EVIDENCE OF INVOLVEMENT OF THE KININ SYSTEM IN MOUSE MALARIA
- Direct observation of microcirculation of the basal region of rat gastric mucosa
- Correlation Inequalities and Lower Bounds for the Critical Value λ_c of Contact Processes
- Applications of the CAM Based on a New Decoupling Procedure of Correlation Functions in the One-Dimensional Contact Process
- ACCELERATION OF ENDOGENOUS PGI2 GENERATION FROM ISOLATED RAT AORTAE BY MK-447
- DUAL EFFECTS OF A BASIC ANTI-INFLAMMATORY AGENT, 2-AMINOMETHYL-4-t-BUTYL-6-IODOPHENOL HYDROCHLORIDE (MK-447), ON BIOSYNTHESIS OF PROSTAGLANDIN ENDOPEROXIDES
- A Second-Order Phase Transition as a Limit of the First-Order Phase Transitions-Coherent Anomalies and Critical Phenomena in the Potts Models-
- Roles of Arachidonate Metabolites in Thrombus Formation and Leukocyte Migration : Analyses At Microcirculatory Level
- Upper Bounds for Order Parameters of a Class of Attractive Nearest-Particle Systems with Finite Ranges
- Applications of the Harris-FKG Inequality to Upper Bounds for Order Parameters in the Contact Processes
- Three-Point Markov Extension and an Improved Upper Bound for Survival Probability of the One-Dimensional Contact Process
- Extreme value distributions of noncolliding diffusion processes (Spectra of Random Operators and Related Topics)
- Scaphoid nonunion and distal fragment resection : analysis with three-dimensional rigid body spring model
- Coherent Anomaly Method in Critical Phenomena.II.Applications to the Two-and Three-Dimensional Ising Models
- Coherent-Anomaly Method in Critical Phenomena.V. Estimation of the Dynamical Critical Exponent Δ of the Two-Dimensional Kinetic Ising Model
- Statistical Properties of Trajectories of Friendly Walkers on Spatio-Temporal Plane : General Physics
- New Method to Study Critical Phenomena-Mean-Field Finite-Size Scaling Theory
- Scaling Laws of the Nonlinear Part of Magnetization in the SK Model of Spin Glasses : Condensed Matter and Statistical Physics
- Structural and Statistical Properties of Competing Directed Percolation
- On the CAM Canonicality of the Cluster-Variation Approximations
- The Number of Directed Compact Site Animals and Extrapolation Formula of Directed Percolation Probability
- Study of Coherent Anomalies and Critical Exponents Based on the Cluster-Variation Method
- n-State Exclusive diffusion Models for Avalanche Processes Showing Self-Organized Criticality
- Low-Density Series Expansion for the Domany-Kinzel Model : General Physics
- Analysis of Canopy-Gap Structures of Forests by Ising-Gibbs States-Equilibrium and Scaling Property of Real Forests-
- Exclusive Diffusion Model Showing Self-Organized Criticality
- Chiral Potts Models,Friendly Walkers and Directed Percoltion Problem
- Biphasic Accumulation of Leukocytes in Rat Cardiac Infarct Tissue Caused by Leukotriene B4 and Complement
- Pivotal Role of Renal Kallikrein-Kinin System in the Development of Hypertension and Approaches to New Drugs Based on This Relationship
- Fractal Structure of Isothermal Lines and Loops on the Cosmic Microwave Background
- A Missing Link Between a High Salt Intake and Blood Pressure Increase
- Effect of Erythropoietin on Angiogenesis With the Increased Adhesion of Platelets to the Microvessels in the Hind-Limb Ischemia Model in Mice
- Roles of prostaglandins in facilitation of angiogenesis in vivo
- Fermi Partition Functions of Friendly Walkers and Pair Connectedness of Directed Percolation : General Physics
- Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis
- Sodium Accumulation Induces Hypertension in Kininogen Deficient Brown Norway Katholiek Rats
- A Stable Metabolite, Arg-Pro-Pro-Gly-Phe, of Bradykinin in the Degradation Pathway in Human Plasma.
- Diuretic and Natriuretic Effect of Ebelactone B in Anesthetized Rats by Inhibition of a Urinary Carboxypeptidase Y-Like Kininase.
- Enhancement of Endogenous Prostaglandin I2 (Prostacyclin) Generation In Vivo by a Phenolic Anti-Inflammatory Agent in the Rabbit.
- Decreased activity of prostaglandin endoperoxide synthetase in prostaglandin I2 (prostacyclin). Biosynthesis from arachidonic acid in isolated rat aortae.
- VEGFR1 signaling facilitates diabetic skin wound healing in mice