Diuretic and Natriuretic Effect of Ebelactone B in Anesthetized Rats by Inhibition of a Urinary Carboxypeptidase Y-Like Kininase.
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概要
- 論文の詳細を見る
Ebelactone B (EB) (10<SUP>-7</SUP>-10<SUP>-5</SUP> M) inhibited dose-dependently carboxypeptidase (CP) Y-like exopeptidase, one of the major kininases separated from rat urine, whereas it inhibited neither CPA, CPB or neutral endopeptidase (NEP). Degradation of bradykinin (BK) to BK-(1-8) in rat urine was completely inhibited by EB (10<SUP>-5</SUP> M) with the increased generation of BK-(1-7). Intraduodenal administration of EB (3 mg/kg) to anesthetized rats caused marked diuresis (by 110%) and natriuresis (130%), in parallel with the increase in urinary kinin levels (110%). Intravenous infusion of a BK antagonist, Hoe140 (3 mg/kg/hr), strongly blocked both EB-induced diuresis and natriuresis. EB may be a novel type of diuretic and natriuretic agent that acts by increasing urinary kinin levels.
- 公益社団法人 日本薬理学会の論文
著者
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KATO Hisao
National Cardiovascular Center Research Institute
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Adachi Keiichi
Department Of Chemistry Faculty Of Science Shizuoka University
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Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
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Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
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KURIBAYASHI Yoshikazu
Department of Pharmacology, Kitasato University School of Medicine
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Ikeda Yasuhiro
Department Of Cardiovascular Medicine Yamaguchi University
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AOYAGI Takaaki
Showa College of Pharmaceutical Sciences
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Ikeda Yasuhiro
Department of Pharmacology, Kitasato University School of Medicine
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