Preoperative body mass index and outcomes of gastric cancer patients
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概要
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<B>Background:</B> The influence of lower body mass index on the survival in cancer patients has not been fully estimated. While, many studies suggest that body mass index were positively associated with an increased risk of cancers of the esophagus, colon, gallbladder, pancreas, breast, endometrium, kidney, and ovary, so the rapid growth in the prevalence of obesity as new threats foretells health problems in years to come.<BR><B>Methods:</B> We assessed preoperative body mass index (BMI) of 2677 patients with malignant and benign diseases who enrolled in the data base for The Japanese Society of strategies of Cancer research and Therapy from May 1975 to February 2004, for evaluating how BMI effect on the outcomes of patients, with examining some parameters.<BR><B>Results:</B> During the period of this study from 1975-, the median BMI increased from 21.6 kg/m<SUP>2</SUP>, 21.9 kg/m<SUP>2</SUP>, 21.9 kg/m<SUP>2</SUP>, and 22.2 kg/m<SUP>2</SUP>, to 22.4 kg/m<SUP>2</SUP>. Serum gastrrin levels, T-IGR, SA, IAP, and CEA were increased significantly than those in both normal and obesity patients. The 10-year-survival rates (disease specific death) of patients of underweight, normal, overweight, and obese were 38.0 (52.0) %, 58.7 (69.5) %, 68.5 (77.4) %, and 54.3 (62.6) %, respectively. (Fig. 3 left) There were significant differences among these groups. (Underweight vs. normal, overweight, and obese, p<0.001, p<0.001, and p=0.042. normal vs. overweight, p<0.001)<BR><B>Conclusions:</B> We found that underweight as well as obese not but overweight patients were shown poor survival rates, and that underweight group showed older persons with lower acid output, higher gastrinemia, higher serum levels of IAP, sialic acid, and CEA than normal weight and overweight group. These findings of this study suggest that underweight group also alterations in growth factors and acute phase reactants. This needs to be investigated in other samples and populations.
- 日本癌病態治療研究会の論文
著者
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Ogoshi Kyoji
Department of Gastroenterological Surgery, Tokai University
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Isono Kaichi
President of Chiba University
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