Inhibitory Effect of Simultaneous Intraportal Administration of 5-Fluorouracil, Uracil and Degradable Starch Microspheres on Experimental Hepatic Micrometastas, is of Colon Cancer
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to examine the optimal regimen of 5-fluorouracil (5-FU), uracil and degradable starch microspheres (DSM) to prevent the hepatic metastasis of colorectal cancer. BALB/C mice were used as a model of hepatic micrometastasis of mouse transplantable colorectal cancer, Colon 26. We intraportally administered to the mice 5-FU at a dose of 34.8mg/kg body weight; uracil at the dose equal to, or 8 times higher than, that of 5-FU in molar weight; and DMS at a dose of 5mg/kg body weight We investigated the hepatic and serum concentrations of 5-FU and uracil and the inhibitory effect of various combinations of the three substances on hapatic metastasis. The study showed that concurrent use of 5-FU with uracil at a dose 8 times higher than that of 5-FU could keep 5-FU concentration high in hepatic tissue and relatively low in serum. This tendency became more marked with the presence of DSM. These findings support the previous study results that uracil antagonizes breakdown of 5-FU in the liver, and with the aid of DSM, retards excretion of 5-FU from the liver. Further investigations for clinical application of this method will lower the incidence of hepatic metastasis of colorectal cancer.
- 東海大学の論文
著者
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FUJII Koichi
Department of Biomaterials Science, Graduate School of Medical and Dental Sciences, Kagoshima Univer
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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MITOMI Toshio
Department of Surgery, School of Medicine, Tokai University
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YASUDA Seiei
Departments of' Urology and Surgery, Tokai University School of Medicine
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Mitomi Toshio
Department Of Surgery (division Of Pediatric Surgery) Tokai University School Of Medicine
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KUROSAWA Tsutomu
Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
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Yasuda S
Himedic Imaging Center At Lake Yamanaka
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Yasuda Seiei
東海大学 医学部外科学
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Yasuda Seiei
Department Of Surgery Tokai University School Of Medicine
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Yasuda S
Tokai Univ. School Of Medicine
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Miwa T
Tokai Univ. School Of Medicine Kanagawa Jpn
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Yasuda Seiei
Department Of Gastroenterological Surgery Tokai University School Of Medicine
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Tajima Tomoo
Department Of Surgety Tokai University School Of Medicine
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Tajima Tomoo
Department Of 2nd Surgery School Of Medicine Tokai University
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Tajima Tomoo
Department Of Surgery Tokai University School Of Medicine
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Fujii Koichi
Second Department Of Surgery Tokai University School Of Medicine
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NAKASAKI Hisao
Department of General Surgery, School of Medicine, Tokai University
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Yasuda Seiei
Himedic Imaging Center At Lake Yamanaka Keio University School Of Medicine
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HANAUE Hitoshi
Departments of Surgery Tokai University Oiso Hospital
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Hirakawa Hitoshi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Nakasaki Hisao
Department Of Surgery Tokai University Oiso Hospital
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Nakasaki H
Department Of Surgery Tokai University School Of Medicine
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Nakazaki Hisao
Department Of Pathology School Of Medicine Tokai University
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Fujii Koichi
Department Of Biomaterials Science Graduate School Of Medical And Dental Sciences Kagoshima Universi
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Machimura Takao
Second Department Of Surgery Tokai University School Of Medicine
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Yokoyama Seishichi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Mitomi Toshio
Second Department Of Surgery Tokai University School Of Medicine
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Mitomi T
Department Of Surgery Tokai University School Of Medicine
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Mitomi Toshio
Department Of 2nd Surgery School Of Medicine Tokai University
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Murakami T
Department Of Critical Care And Emergency Medicine Tokai University School Of Medicine
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Kurosawa Tsutomu
Institute For Experimental Animal Sciences Osaka University Medical School
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Nakasaki H
Department Of Surgery Tokai University Oiso Hospital
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Fujii Koichi
Department Of Biomaterials Science Field Of Oral And Maxillofacial Rehabilitation Course For Advance
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HANAUE HITOSHI
Department of Surgery, Fujita-Gakuen University School of Medicine
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Miyashita Kayoko
DIMS Institute of Medical Science:Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
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Kawabe Mayumi
Department of Surgery, Tokai University School of Medicine
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