Endoscopic Manometry of the Sphincter of Oddi in Dogs Pharmacological Effects of Anticholinergic and Selective Antimuscarinic Agents
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概要
- 論文の詳細を見る
A dog model was used for direct measurement of the sphincter of Oddi using endoscopy. The effects of anticholinergic agents and a selective antimuscarinic agent on the canine sphincter of Oddi motility were studied. Manometric tracing at the canine sphincter showed rhythmical phasic contractions which were not affected by respiration. The mean values of the basal motility were as follows: the peak pressure was 61.5±2.2 (m±SE) cmH_2O, trough pressure was 21.8±1.2 cmH_2O, and the frequency was 17.4±0.2 waves/min. Intravenous administration of atropine sulfate, butropium bromide, butylscopolamine bromide and also pirenzepine significantly reduced the amplitude and frequency of canine sphincter contractions. From these results, it appeared that the cholinergic autonomic nervous system might be the one of the regulators of the canine sphincter of Oddi activity.
- 東海大学の論文
著者
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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Kikuchi Kazuhiro
Department Of Internal Medicine School Of Medicine Tokai University
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Kikuchi Kazuhiro
東海大学 内科
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HARASAWA Shigeru
Department of Internal Medicine, Tokai University School of of Medicine
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Kikuchi Kazuhiro
Department Of Animal Science National Institute Of Agrobiological Sciences
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Mitomi Toshio
Second Department Of Surgery Tokai University School Of Medicine
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Miwa Takeshi
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Harasawa Shigeru
Department Of Internal Medicine School Of Medicine Tokai University
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Harasawa Shigeru
Division Of Gastroenterology Ii Tokai University School Of Medicine
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Harasawa Shigeru
Department Of Gastroenterology Ii Tokai University School Of Medicine
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Miwa Takeshi
Department Of Internal Medicine 6 Tokai University School Of Medicine
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Miura Toshihiro
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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