Circadian Rhythm of Anti-Cancer Drug Target Topoisomerase I As a Proposal Model for Chronotherapy In Vitro
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概要
- 論文の詳細を見る
Many behavioral processes are under circadian regulation in almost all organisms from bacteria to mammals. Although substantial evidences support the idea that circadian clock could modulate the efficacy of anticancer therapy, the mechanism(s) has not been clear. Here we demonstrated that expression of topoisomerase I (top1) mRNA and its promoter activity underwent circadian oscillation after serum-rich medium treatment in HCT 116 cells. Moreover, the formation of cleavage complex composed of top1 and top1 poison, camptothecin (CPT), detected by nicking assay was also oscillated. Colony formation assay indicated that cytotoxicity of 8h-CPT treatment was significantly higher at 4-h after serum-shock than at 20-h (p = 0.0289). In addition, dexamethasone treatment also induced circadian rhythm of top1 in HCT 116 cells. These results raise the possibility that the circadian rhythm of top1, which would be induced by some types of drugs such as dexamethasone, could be considered for chemotherapy in clinic.
著者
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SAKAMOTO Wataru
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Koyama Yoshihisa
Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine
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Takebayashi Yuji
Department Of Cancer Chemotherapy Institute For Cancer Research
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Watanabe Yohei
Department Of Microbiology And Immunology Tohoku University Graduate School Of Medicine
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Iwadate Manabu
Department Of Surgery Ii Fukushima Medical University
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Abe Noriko
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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Hayase Suguru
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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Saito Masaru
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Miyamoto Kotaro
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine
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TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
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Watanabe Kumiko
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ono Koichiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ono Tomojiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sakamoto Wataru
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Kikuchi Daiki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University
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