Presence of Circadian oscillation of Multidrug Resistance Gene 1 in KB-C2 cell line
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概要
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Many physiological, biochemical and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock in almost all organisms from bacteria to mammals. Although the substantial evidences that the circadian clock could modulate the morbidity and efficacy of anticancer therapy have been proposed, underlying mechanisms for chronotherapy has been only poorly elucidated, and it has not been popular in clinic. The aim of this study was to determine the relationship between the expression of P-glycoprotein (P-gp)/MDR1, which is one of the important molecules in anti-cancer drug resistance, and circadian rhythm in KB-C2 cells. The present study demonstrated that both MDR1 expression level and its promoter activity oscillated after treatment with high concentration of fetal bovine serum. Moreover, cytotoxic effect of taxol were dependent on the fluctuated levels of MDR1. These results suggest that the circadian rhythm of MDR1 may have an influential effect on cytotoxicity of anti-cancer drug and could be available for chemotherapy in clinic.
著者
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SAKAMOTO Wataru
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Koyama Yoshihisa
Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine
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Takebayashi Yuji
Department Of Cancer Chemotherapy Institute For Cancer Research
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Iwadate Manabu
Department Of Surgery Ii Fukushima Medical University
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Abe Noriko
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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Saito Masaru
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Kobayashi Yusuke
Department Of Genome System Science Yokohama City University
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Miyamoto Kotaro
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
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Ito Testuro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ono Koichiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Higashimoto Masashi
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ando Jin
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Noda Masaru
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Yoshida Tuneyuki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ohshima Takasi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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