Efficacy of 5-fluorouracil on Tumor Growth in Walker -256 Xenografted rat. Mice is dependent on Circadian Rhythm
スポンサーリンク
概要
- 論文の詳細を見る
Chronotherapy is one of the most active treatment schedule, based on the adjustment of drug delivery to the 24-hour rhythms generated by circadian rhythm. The aim of this study is to confirm that the efficacy of 5-fluorouracil (5-FU) is dependent on circadian rhythm, using Walker-256 xenografted rat. The present study demonstrated that tumor developed more rapidly at night rather than at day. Moreover, the administration of 5-FU at night was more effective rather than that at day. Furthermore, the microvessel count by immunohistochemical staining of endothelial cells revearled that tumors treated with 5-FU at night contained significantly less microvessels than those at day. In conclusion, our present data suggested that chronotherapy would contribute to the improvement of chemotherapy in patients with some population of malignancy through the control of angiogenesis.
著者
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SAKAMOTO Wataru
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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OKOUCHI Chiyo
Department of Surgery Hoshi General Hospital
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Koyama Yoshihisa
Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine
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Takebayashi Yuji
Department Of Cancer Chemotherapy Institute For Cancer Research
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Watanabe Yohei
Department Of Microbiology And Immunology Tohoku University Graduate School Of Medicine
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OHSHIMA Takashi
Department of Agricultural Chemistry, Utsunomiya University
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Kofunato Yasuhide
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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Sakuma Hiroshi
Department Of Child Neurology National Center Hospital For Mental Nervous And Muscular Disorders
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TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
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Hoshino Masami
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Kofunato Yasuhide
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sato Tadahiko
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Monnma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Saitou Masaru
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Fujita Shoutaro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Imaizumi Hideko
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Tsuda Morihiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Onozawa Hisashi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Takenoshita Seiichi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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