Rituximab Treatment for Adult Purpura Nephritis with Nephrotic Syndrome

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概要

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• The case of a 68-year-old woman with purpura nephritis associated with nephrotic syndrome is herein described. The patient's clinical course and the findings of a renal biopsy study revealed purpura nephritis. Following treatment with corticosteroids and intravenous cyclophosphamide accompanied by an angiotensin II type I receptor-blocker, an anti-platelet drug and an hydroxymethylglutaryl (HMG)-CoA, the proteinuria mildly decreased. Additional rituximab therapy led to a complete remission. This report describes our successful experience using rituximab to treat refractory nephrotic syndrome of purpura nephritis. Further studies are required to confirm the efficacy of rituximab as an alternative therapy for nephrotic syndrome.

著者

• Toya Yoshiyuki

  Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine

• Wakui Hiromichi

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M

• Kanaoka Tomohiko

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M

• Oshikawa Jin

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine

• Hashimoto Tatsuo

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine

• Inayama Yoshiaki

  Department Of Pathology And Laboratory Medicine Yokohama City University

• Tamura Kouichi

  Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M

• Nagahama Kiyotaka

  Department Of Pathology Toranomon Hospital

• Umemura Satoshi

  Department Of Internal Medicine Ii Yokohama City University School Of Medicine

• Ishiguro Hiroaki

  Department Of Dermatology Kochi Medical School

• Kobayashi Yusuke

  Department Of Genome System Science Yokohama City University

• Yoshida Shinichiro

  Department Of Internal Medicine Nagasaki National Medical Center

• Suzuki Shota

  Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Sci

• AZUSHIMA Kengo

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine

• Tamura Kouichi

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

• Yoshida Shinichiro

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

• Kanaoka Tomohiko

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

• Kobayashi Yusuke

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

• Akata Mariko

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

• Hashimoto Tatsuo

  Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Japan

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