Effect of sodium restriction on platelet function in patients with essential hypertension.
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概要
- 論文の詳細を見る
The effects of sodium intake on blood pressure and platelet function were evaluated in 19 subjects with essential hypertension (10 men and 9 women; mean age 49.7 years). The study was conducted under 3 conditions: (1) normal sodium diet (12g/day of salt was used in cooking), (2) after 5 days of mild sodium restriction diet (6g/day of salt was used in cooking) and (3) after moderate sodium restriction (no salt was used in cooking). Blood pressure was significantly reduced following sodium restriction without any change in heart rate. The ratio of the plasma level of β-thromboglobulin to platelet factor IV, regarded as the most reliable index for platelet activation in vivo, increased significantly after mild sodium restriction; this change was maintained after moderate sodium restriction. Plasma thromboxane B2, a stable metabolite of thromboxane A2, increased significantly after sodium restriction; the level of 6-keto-prostaglandin F1α, a stable metabolite of prostacyclin, was unaffected. These results indicate that dietary sodium restriction induces both a reduction of blood pressure and an activation of platelet function in vivo. Thus, one must consider both antihypertensive effects and effects on platelet function as factors in adjusting the dietary sodium intake in the course of antihypertensive therapy.
- International Heart Journal刊行会の論文
著者
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Toya Yoshiyuki
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Yuhara Mikio
Department of Cardiology, Saitama Medical Center, Saitama Medical University
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Gomi Tomoko
Department Of Nephrology Kanto Medical Center Ntt Ec
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Ikegami Fumiaki
Department Of Gastroenterology Kanto Teishin Hospital
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Sakurai Jun
Department Of Diagnostic Radiology Kagawa Prefectural Central Hospital
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Ikeda Toshio
Department Electronic Engineering Faculty Of Engineering Tohoku University
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FUJINAMI Kenji
Department of Nephrology, Kanto-Teishin Hospital
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IKEGAMI Fumiaki
Department of Nephrology, Kanto-Teishin Hospital
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