Effects of Swim Training on Blood Pressure, Catecholamines and Prostaglandins in Spontaneously Hypertensive Rats.
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概要
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A 6-month program of exercise with a daily swimming time of 30 minutes 3 times a week was carried out in female spontaneously hypertensive rats (SHR) to assess the roles of catecholamine and prostaglandin metabolism in the antihypertensive effect of chronic exercise conditioning. Swim training resulted in a significant reduction of mean blood pressure in SHR by 13.3mmHg as compared with sedentary controls (158.8±5.0 versus 172.1±3.3mmHg, p<0.05). The increase in plasma levels of norepinephrine and epinephrine after acute blood loss of 2% of body weight were smaller in trained than control SHR. The daily urinary excretion of thromboxane B2, a stable metabolite of thromboxane A2, was significantly decreased by 33% in swim trained SHR as compared with control SHR (p<0.01), while there was no difference in urinary excretion of prostaglandin E2 or 6-keto-prostaglandin F1α, a stable metabolite of prostacyclin. These findings indicate that both the suppression of the sympathoadrenal system and decrease in vasoconstrictory prostaglandins in the kidney may have shared in the antihypertensive effect of exercise training in SHR.
- International Heart Journal刊行会の論文
著者
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Sasaki Yuzo
Department Of Physics Tokyo Institute Of Technology
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Gomi Tomoko
Department Of Nephrology Kanto Medical Center Ntt Ec
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Ikeda Toshio
Department Electronic Engineering Faculty Of Engineering Tohoku University
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GOMI Tomoko
Department of Nephrology, NTT Kanto-Teishin Hospital
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SASAKI Yuzo
Department of Nephrology, NTT Kanto-Teishin Hospital
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