THE EFFECTS OF SEX STEROIDS AND OVULATION INDUCING STIMULI ON THE HYPOTHALAMUS AND THE LIMBIC SYSTEM

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It is a well known conception that the hypothalamo-hypophysio-ovarian system constitutes an axis on gonadal function. Recently, it was found that the limbic system played an important role on the mechanism of ovulation. In order to clarify the co-relation between the hypothalamus and the limbic system, the electrical activities of the brain of 20 ovariectomized mature New Zealand white rabbits were examined. Two different EEG phenomena were applied for this investigation, i.e., (1) EEG afterreaction on the hypothalamus and (2) after-discharge on the limbic system. The alteration of brain activity was indicated by the electrical threshold, duration and latency of these two EEG phenomena. The results were as follows;(1) The activities of these areas revealed typical biphasic changes-excitatory and then depressed-when 10 mg of either progesterone or retro-progesterone were injected subcutaneously. The inhibitory effects on the hippocampus was, however, not evident.(2) By intravenous injection of 0.08mg of estradiol benzoate, hypothalamic activity was depressed slightly and briefly. The threshold of the amygdaloid discharge remained unchanged, while that of the hippocampus, however, was markedly depressed.(3) Three mg of Compound F6066, non-steroidal estrogenic substance, showed an effect quite similar to that of estrogen.(4) Bitemporal indirect pulse stimulation, which is applied for clinical induction of ovulation, revealed excitatory effects for one hr. and a half on the hypothalamus as well as on the limbic system.
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THE EFFECTS OF SEX STEROIDS AND OVULATION INDUCING STIMULI ON THE HYPOTHALAMUS AND THE LIMBIC SYSTEM

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