EFFECTS OF MORPHINE ON THE SERUM PROLACTIN LEVELS OF MORPHINE-TOLERANT AND NONTOLERANT MALE RATS AND ON THE <I>IN VITRO</I> RELEASE OF PITUITARY PROLACTIN
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概要
- 論文の詳細を見る
Morphine increased the serum prolactin (PRL) levels of male rats in a dose response manner. This effect was abolished by naloxone and apomorphine, but was not affected by diphenhydramine. The increase in the serum PRL levels by haloperidol was abolished by apomorphine, but not by naloxone. Repeated administrations of increasing doses of morphine attenuated the response of serum PRL to morphine. Naloxone did not alter the serum PRL levels of morphine-tolerant rats, while it precipitated full withdrawal signs on these rats. Although neither haloperidol nor morphine increased the release of PRL from the isolated anterior pituitary, haloperidol, but not morphine, reversed the inhibition by dopamine of the <I>in vitro</I> release of pituitary PRL. These results indicate that tolerance develops regarding the effect of morphine with a resulting increase in the serum PRL levels, abstinence precipitated by naloxone has no effect on the serum PRL levels, the mechanism of morphine involved in increase in the serum PRL is different from that of haloperidol as the effect of haloperidol is not antagonized by naloxone and morphine does not antagonize the effect of dopamine which inhibits the release of PRL from the anterior pituitary <I>in vitro</I>.
- 社団法人 日本薬理学会の論文
著者
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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TOKUNAGA Yukiko
Department of Pharmacology, School of Medicine, Keio University
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Tokunaga Yukiko
Department Of Pharmacology School Of Medicine Keio University
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MURAKI Takamura
Department of Pharmacology, School of Medicine, Keio University
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