Failure of morphine to affect phospholipid metabolism in superior cervical sympathetic ganglion of rats in vitro.
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概要
- 論文の詳細を見る
The effect of morphine on phospholipid metabolism in superior cervical sympathetic ganglion of rats was investigated in vitro. The dissected sympathetic ganglion was incubated in standard bathing solution with 32P inorganic phosphate and the incorporation of radioactivity into phospholipid was measured. The rate of 32P incorporation into total phospholipid was linear between one and four hour incubation. Three hour incubation of sympathetic ganglion in 10-4M morphine did not alter the phospholipid metabolism of both resting and acetylcholine-stimulated ganglia, in spite of the definite depressive effect at this concentration of morphine on the electrophysiological activity of ganglion cells. This result suggests that the depressant effect of morphine on sympathetic ganglion is not directly related to changes of phospholipid metabolism in sympathetic ganglion.
- The Keio Journal of Medicineの論文
著者
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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HOSOYA Eikichi
Department of Pharmacology, School of Medicine, Keio University
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Nagata Yutaka
Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ
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HOSOYA EIKICHI
Department of Pharmacology, School of Medicine Keio University
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MURAKI Takamura
Department of Pharmacology, School of Medicine, Keio University
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MURAKI TAKAMURA
Department of Dermatology, School of Medicine, Keio University
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