EFFECTS OF REPEATED MORPHINE ADMINISTRATION ON COPULATION AND ON THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS OF MALE RATS
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概要
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Adult male rats were administered morphine twice a day for 45 days and the effects of morphine on the copulation rate, the weight of various organs, and on the hypothalamic-pituitary-gonadal axis were examined. Morphine administered rats showed a loss of weight, hypertrophy of the adrenals, decreased weight of accessory sex organs, low sperm count, and decreased copulation rate. The contents of the luteinizing hormone releasing hormone in the hypothalamus and the luteinizing hormone in the pituitary remained unchanged. Serum luteinizing hormone and testosterone levels decreased, but serum follicle-stimulating hormone levels increased. These results suggest that morphine inhibits the hypothalamic-pituitary-gonadal axis and causes a diminution in the number of fertilizations of the partner females.
著者
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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HOSOYA Eikichi
Department of Pharmacology, School of Medicine, Keio University
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Tokunaga Yukiko
Department Of Pharmacology School Of Medicine Keio University
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HOSOYA EIKICHI
Department of Pharmacology, School of Medicine Keio University
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MURAKI TAKAMURA
Department of Dermatology, School of Medicine, Keio University
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