Trypanocidal Constituents from Michelia alba
スポンサーリンク
概要
- 論文の詳細を見る
The AcOEt extract of the bark of M. alba DC. (Magnoliaceae) exhibited killing activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded eight trypanocidal constituents; caryophyllene oxide (1), costunolide (2), dihydrocostunolide (3), parthenolide (4), dihydroparthenolide (5), 1 1,13-dehydrolanuginolide (6) santamarine (7) and a new monoterpene (8). The structure of monoterpene 8 was determined to be dehydrolinalool oxide on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 61 μM, 7 μM, 27 μM, 0.04 μM, 0.78 μM, 0.16 μM, 25 μM, and 5 μM, respectively.
- 日本生薬学会の論文
- 2003-04-20
著者
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Aoki T
Tohoku Univ. Sendai‐shi Jpn
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Nakajima-shimada Junko
Juntendo Univ. School Of Medicine Tokyo Jpn
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Aoki Takashi
School Of Health Sciences Kyushu University
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TSUBOUCHI Akiko
School of Medicine, Juntendo University
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Tsubouchi A
Juntendo Univ. School Of Medicine Tokyo Jpn
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Kiuchi F
Graduate School Of Pharmaceutical Sciences Kyoto University
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Kiuchi Fumiyuki
国立医薬品衛生研究所
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Kikuchi F
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu
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Kikuchi F
Faculty Of Pharmaceutical Sciences Kanazawa University
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ASARUDDIN Mohd
Graduate School of Pharmaceutical Sciences, Kyoto University
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Asaruddin Mohd
Graduate School Of Pharmaceutical Sciences Kyoto University
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Kiuchi Fumiyuki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Nakajima-shimada Junko
School Of Medicine Juntendo University
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Honda G
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Honda Gisho
Graduate School Of Pharmaceutical Sciences Kyoto University
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Honda Gisho
Faculty Of Pharmaceutical Sciences Himeji Dokkyo University
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Kiuchi Fumiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu
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Aoki T
School Of Medicine Juntendo University
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