Novel A-Seco-Rearranged Lanostane Triterpenoids from Abies sachalinensis
スポンサーリンク
概要
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From the needles of Abies sachalinensis, novel rearranged lanostane type triterpenes, 1-4,were isolated along with a known triterpene (5). The structures of the new compounds, 1-4,were elucidated to be 3,4-seco-8-(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7,14(30), 22Z, 24-pentaen-26,23-olide-3-oic acid, methyl 3,4-seco-8-(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7,14(30), 22Z, 24-penten-26,23-olide-3-oate, 3,4-seco-8(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7,14,22Z, 24-pentaene-26,23-olide-3-oic acid and methyl 3,4-seco-8(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7,14,22Z, 24-pentaene-26,23-olide-3-oate, respectively, by means of spectral experiments, especially two dimensional NMR spectroscopy, such as ^1H-detected multiple quantum coherence (HMQC), ^1H-detected heteronuclear multiple bond connectivity (HMBC) and ^1H-^1H-correlation spectroscopy (COSY) experiments. These new compounds have novel structures containing A-seco, rearranged spiro structure and a γ-lactone conjugated with a diene. Some of these compounds showed potent antibacterial activity against gram positive bacteria.
- 公益社団法人日本薬学会の論文
- 2000-12-01
著者
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KAWAHARA Nobuo
National Institute of Health Sciences
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KUROYANAGI Masanori
School of Bioresources, Hiroshioma Prefectural University
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Kanazawa Michiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kanazawa Masahiro
Takuho Industry
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Sugiyama K
School Of Pharmaceutical Sciences University Of Shizuoka
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SUGIYAMA Kazumasa
School of Pharmaceutical Sciences, University of Shizuoka
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Kuroyanagi Masanori
School Of Bioresources Hiroshima Prefectural University
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Sugiyama Kazumasa
School Of Pharmaceutical Sciences University Of Shizuoka
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Kawahara Nobuo
National Inst. Health Sci. Tokyo Jpn
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