Cell Differentiation Inducing Steroids from Withania somnifera L. (DUN.)
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概要
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In the course of screening for cell differentiation inducers from botanical sources, the methanol extract of Withania somnifera L. (DUN.) showed activity. From the aerial parts of the plant, sixteen withanolides, including three new compounds, 14,15 and 16,were isolated and their structures elucidated to be (20S, 22R)-4β, 5β, 6α, 27-tetrahydroxy-1-oxo-witha-2,24-dienolide, (20R, 22R, 24S, 25R)-4β, 20β-dihydroxy-5β, 6β-epoxy-3β-methoxy-1-oxo-withanolide and 3-O-[β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]-(20S, 22R)-1α, 3β-dihydroxywitha-5,24-di-enolide, respectively, from the spectral data. Of these withanolides, 1,2,3 and 4 showed potent cell differentiation inducing activity against M1 cells. The most potent compound, 3,showed more potent activity than dexamethasone, the positive control. These active compounds have the same partial structure of the AB ring part, having a 4β-hydroxy-5β, 6β-epoxy-2-en-1-one moiety.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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UMEHARA Kaoru
School of Pharmaceutical Sciences, University of Shizuoka
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KUROYANAGI Masanori
School of Bioresources, Hiroshioma Prefectural University
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Umehara Kaoru
School Of Pharmaceutical Sciences University Of Shizuoka
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Kuroyanagi Masanori
School Of Bioresources Hiroshima Prefectural University
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SHIBATA Kazutoshi
School of Pharmaceutical Sciences, University of Shizuoka
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Shibata Kazutoshi
School Of Pharmaceutical Sciences University Of Shizuoka
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