Antichagasic Activities of Natural Products against Trypanosoma cruzi
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概要
- 論文の詳細を見る
Trypanosoma cruzi (T. cruzi) is a parasitic protozoan transmitted to mammalian hosts by blood-sucking triatomine bugs. Infections by T. cruzi, known as Chagas' disease, pose a major public health problem in endemic countries in Central and South America. New chemotherapeutic agents are desired because of the lack of effective vaccines, undesirable side effects of anti-chagasic drugs in use such as nifurtimox and benznidazole, and the emergence of parasite resistance to these drugs. In the past two decades, novel advances and an improved understanding of the biology and biochemistry of T. cruzi have led to the identification of various targets for chemotherapy to treat Chagas' disease. In addition, many efforts have been undertaken to develop antichagasic agents, such as designed and synthesized compounds, natural products, and their derivatives, against a number of targets. Here, I mainly review recent studies on the antichagasic activities of natural products.
- 2009-02-01
著者
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Uchiyama Nahoko
National Institute Of Health Sciences
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Uchiyama Nahoko
National Institute Of Health Sciences (nihs)
関連論文
- Trypanocidal Terpenoids from Laurus nobilis L.
- Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi
- Two Phenylpropanoid Glycosides from Neopicrorhiza scrophulariiflora
- Antichagasic Activities of Natural Products against Trypanosoma cruzi
- Identification of a Cannabinoid Analog as a New Type of Designer Drug in a Herbal Product(Communications to the Editor)
- Determination of a New Type of Phosphodiesterase-5 Inhibitor, Thioquinapiperifil, in a Dietary Supplement Promoted for Sexual Enhancement
- Communication to the editor: Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB1 and CB2 receptors
- Flavonoid Constituents of Dracocephalum kotschyi Growing in Iran and Their Trypanocidal Activity
- Structural insight into the stereoselective production of PGF_ by Old Yellow Enzyme from Trypanosoma cruzi
- Identification of a Novel Cannabimimetic Phenylacetylindole, Cannabipiperidiethanone, as a Designer Drug in a Herbal Product and Its Affinity for Cannabinoid CB1 and CB2 Receptors