Effects of Oral Administration of Glucosylceramide on Gene Expression Changes in Hairless Mouse Skin: Comparison of Whole Skin, Epidermis, and Dermis
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概要
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The beneficial effects of dietary glucosylceramide on the barrier function of the skin have been increasingly reported, but the entire mechanism has not been clarified. By DNA microarray, we investigated changes in gene expression in hairless mouse skin when a damage-inducing AD diet and a glucosylceramide diet (GluCer) were imposed. GluCer administration potentially suppressed the upregulation of six genes and the downregulation of four genes in the AD group. Examination of the epidermal and/or dermal expression of Npr3, Cyp17a1, Col1a1, S100a9, Sprr2f, Apol7a, Tppp, and Scd3 revealed responses of various parts of the skin to the diets. In normal hairless mice, GluCer administration induced an increase in the dermal expression of Cyp17a1 and the epidermal expression of Tppp, and a decrease in the epidermal expression of S100a9. Our results provide information on gene expression not only in whole skin but also in the epidermis and dermis that should prove useful in the search for the mechanisms underlying the effects of GluCer on damaged and normal skin.
著者
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Satsu Hideo
Department Of Applied Biological Chemistry Division Of Agricultural And Life Sciences The University
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Chida Kazuhiro
Department Of Animal Resource Sciences Graduate School Of Agricultural And Life Sciences The Univers
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Totsuka Mamoru
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Iwamoto Taku
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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TOTSUKA Mamoru
Department of Applied Biological Chemistry, The University of Tokyo
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SATSU Hideo
Department of Applied Biological Chemistry, The University of Tokyo
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TAKATORI Ryo
Department of Applied Biological Chemistry, The University of Tokyo
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LE VU
Department of Applied Biological Chemistry, The University of Tokyo
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CHIDA Kazuhiro
Department of Animal Resource Sciences, The University of Tokyo
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CHIDA Kazuhiro
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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