Structures and Activity of Angiotensin-converting Enzyme Inhibitors in an α-Zein Hydrolysate(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Peptides that inhibit angiotensin-converting enzyme (ACE) were isolated from α-zein hydrolysate prepared with thermolysin. Their chemical structures were identified by Edman degradation and fast-atom bombardment mass spectrometry. Most of them were found to be tripeptides such as Leu-Arg-Pro, Leu-Ser-Pro, and Leu-Gln-Pro, having IC_<50> values of 0.27, 1.7, and 1.9 μM, respectively. These peptides were synthesized by a solid phase procedure and had similar ACE inhibitory activities as the isolated inhibitors. The hypotensive activity of Leu-Arg-Pro on spontaneously hypertensive rats was also investigated, with the result that the blood pressure decreased by 15 mmHg after 30mg/kg intravenous injection.
- 社団法人日本農芸化学会の論文
- 1991-05-23
著者
-
Kaneko Tetsuya
Laboratory Of Biochemistry And Nutritional Chemistry Faculty Of Agriculture Kagoshima University
-
KANEKO Toshiyuki
Research and Development Center, Showa Sangyo Co., Ltd.
-
FUKUI Fumio
Research and Development Center, Showa Sangyo Co., Ltd.
-
Kaneko Toshiyuki
Research And Development Center Showa Sangyo Co. Ltd.
-
Fukui F
Showa Sangyo Co. Ltd. Ibaraki Jpn
-
Fukui Fumio
Research And Development Center Showa Sangyo Co. Ltd.
-
Fukui Fumio
Fermentation Research Laboratories Sankyo Co. Ltd.
-
Maruyama Susumu
Fermentation Research Institute
-
Maruyama Susumu
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
-
Maruyama Susumu
National Institute Of Bioscience And Human Technology Agency Of Industrial Science And Technology
-
Kaneko T
Research And Development Center Showa Sangyo Co. Ltd.
-
MIYOSHI Shinsuke
Research and Development Center, Showa Sangyo Co., Ltd.
-
TANAKA Hideoki
Fermentation Research Institute
-
ISHIKAWA Hiromi
Research and Development Center, Showa Sangyo Co., Ltd.
-
Tanaka Hideoki
National Institute Of Bioscience And Human-technology Agency Of Industrial Science And Technology
-
Ishikawa Hiromi
Research And Development Center Showa Sangyo Co. Ltd.
-
Miyoshi S
Showa Sangyo Co. Ltd. Ibaraki Prefecture Jpn
関連論文
- Formation of Monohydroxy-n-Nonane-2-Ones from Tricaprin by Fusarium avenaceum f. sp. fabae IFO 7158
- Metabolism of ^C-Isomaltooligosaccharides in Healthy Men
- Effects of Isomaltooligosaccharides with Different Degrees of Polymerization on Human Fecal Bifidobacteria
- Dose-response Test of Isomaltooligosaccharides for Increasing Fecal Bifidobacteria(Food & Nutrition)
- Subterminal Hydroxylation of Ketoalkanes by Fungi
- A Novel Enzyme System : The n-Alkane-2-One-Forming Enzyme System in Penicillium decumbens IFO-7091
- Formation of n-Alkane-2-Ones and n-Alkane-2-Ols from Triglycerides by a Black Yeast, Aureobasidium
- Methylalkylketone Fermentation from Palm-Kernel Oil by Penicillium decumbens IFO 7091
- Screening of Methylalkylketone-Accumulating Fungi from Type Culture Strains
- Production of Ketoalkanes from Fatty Acid Esters by a Fungus, Trichoderma
- Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats
- Luteolin Inhibits Endothelin-1 Secretion in Cultured Endothelial Cells
- A Synthetic Polymer, Poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), Stimulated Insulin Release from RINm5F Insulinoma Cells
- Angiotensin I-Converting Enzyme Inhibitory Activity and Insulin Secretion Stimulative Activity of Fermented Fish Sauce
- Hypotensive Activity of Enzymatic α-Zein Hydrolysate(Biological Chemistry)
- Structures and Activity of Angiotensin-converting Enzyme Inhibitors in an α-Zein Hydrolysate(Biological Chemistry)
- Angiotensin I-Converting Enzyme Inhibitory Activities of Synthetic Peptides Related to the Tandem Repeated Sequence of a Maize Endosperm Protein(Food & Nutrition)
- PC73 ISOLATION AND STRUCTURE ELUCIDATION OF THREE NEW GLYCOSYLATED VITAMIN B_6 IN RICE BRAN
- Evidence for the Occurrence and Distribution of a New Type of Vitamin B_6 Conjugate in Plant Foods
- Diacetyl Formation and Degradation by Streptococcus lactis subsp. diacetylactis 3022
- Fuzzy Control in Microbial Production of ML-236B, a Precursor of Pravastatin Sodium
- Morphology Control of Preculture during Production of ML-236B, a Precursor of Pravastrain Sodium, by Penicillium citrinum
- New Sulfated Oligosaccharides Produced by Pseudomonas β-Agarase from Gracilaria verrucosa Polysaccharide
- In Vivo Macrophage-stimulation Activity of the Enzyme-degraded Water-soluble Polysaccharide Fraction from a Marine Alga (Gracilaria verrucosa)
- Macrophage Stimulation Activity of the Polysaccharide Fraction from a Marine Alga (Porphyra yezoensis):Structure-Function Relationships and Improved Solubility
- Digestibility of the Hydrogenated Derivative of an Isomaltooligosaccharide Mixture by Rats
- Aminopeptidase P, Capable of Hydrolyzing Oligoproline, from Bovine Brain
- Inhibition of HIV-1 Protease by Water-Soluble Lignin-Like Substance from an Edible Mushroom, Fuscoporia obliqua
- High-Level Secretory Production of Phospholipase A_1 by Saccharomyces cerevisiae and Aspergillus oryzae
- 1019 Cloning and characterization of Δ 9-fatty acid desaturase genes from Pichia, Yarrowia and Kluyveromyces
- Antihypertensive Effect of Enzymatic Hydrolysate of Collagen and Gly-Pro in Spontaneously Hypertensive Rats
- In Vitro and in Vivo Anti-platelet Effects of Enzymatic Hydrolysates of Collagen and Collagen-related Peptides
- Prolylendopeptidase Inhibitory Activity of a Glial Fibrillary Acidic Protein Fragment and Other Proline-rich Peptides
- Prolyl Endopeptidase Inhibitory Activity of Peptides in the Repeated Sequence of Various Proline-Rich Proteins
- Angiotensin I-Converting Enzyme Inhibitors Derived from Ficus carica(Biological Chemistry)
- HIV-1 Protease Inhibition and Anti-HIV Effect of Natural and Synthetic Water-soluble Lignin-like Substances
- Actions of Teleocidins on in Vitro CFU-GM and CFU-E Colony Formation(Biological Chemistry)
- Evaluation of Acidogenicity of Commercial Isomaltooligosaccharides Mixture and Its Hydrogenated Derivative by Measurement of pH Response under Human Dental Plaque
- Digestibility Characteristics of Isomaltooligosaccharides in Comparison with Several Saccharides Using the Rat Jejunum Loop Method
- Purification of angiotensin I-converting enzyme inhibitors in pelagic thresher Alopias pelagicus muscle hydrolysate and viscera extracts
- Process Development for Industrial-Scale Preparation of Carboxypeptidase Y Secreted by Saccharomyces cerevisiae
- Effect of Ethanol on the Production of Carboxypeptidase Y Using the GAL10 Promoter in a Saccharomyces cerevisiae gal80 Mutant
- Inhibition by Aloenin and Barbaloin of Histamine Release from Rat Peritoneal Mast Cells
- Metabolism of Thiophene-2-carboxylate by a Photosynthetic Bacterium
- Angiotensin I-Converting Enzyme Inhibitor Derived from an Enzymatic Hydrolysate of Casein. II. Isolation and Bradykinin-potentiating Activity on the Uterus and the Ileum of Rats
- Studies on the Active Site and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitors Derived from Casein
- Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein
- A Peptide Inhibitor of Angiotensin I Converting Enzyme in the Tryptic Hydrolysate of Casein