Studies on the Active Site and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitors Derived from Casein
スポンサーリンク
概要
- 論文の詳細を見る
The fragment-peptides of angiotensin I-converting enzyme inhibitors (CEI12, CEI5 and CEIβ7) derived from an enzymatic hydrolysate of casein were synthesized. Val-Ala-Pro, the C-terminal tripeptide of CEI5 (Phe-Phe-Val-Ala-Pro), exhibited more potent inhibitory activity (I50=2.0μM) than CEI5 (I50=6.0μM). However, D-Val-Ala-Pro showed lower inhibitory activity (I50=550μM). Val-Ala-Pro may be important for the inhibitory activity of CEI5. The C-terminal heptapeptide of CEI12 (Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val-Phe-Gly-Lys) and the short fragments of CEIβ7 (Ala-Val-Pro-Tyr-Pro-Gln-Arg) showed lower inhibitory activities than the full-length peptides. Also, the antihypertensive activity of CEI12 and CEI5 was investigated. CEI12, intravenously administered to anesthetized rats at 14.2mg/kg, antagonized the rats pressor response to angiotensin I.
- 社団法人 日本農芸化学会の論文
著者
-
Tomizuka Noboru
Fermentation Research Institute
-
Maruyama Susumu
Fermentation Research Institute
-
TANAKA Hideoki
Fermentation Research Institute
-
SUZUKI Hideo
Fermentation Research Institute
-
MITACHI Hajime
Sanwakagaku Kenkyusho Co., Ltd.
関連論文
- Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats
- A Synthetic Polymer, Poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), Stimulated Insulin Release from RINm5F Insulinoma Cells
- Angiotensin I-Converting Enzyme Inhibitory Activity and Insulin Secretion Stimulative Activity of Fermented Fish Sauce
- Hypotensive Activity of Enzymatic α-Zein Hydrolysate(Biological Chemistry)
- Structures and Activity of Angiotensin-converting Enzyme Inhibitors in an α-Zein Hydrolysate(Biological Chemistry)
- Angiotensin I-Converting Enzyme Inhibitory Activities of Synthetic Peptides Related to the Tandem Repeated Sequence of a Maize Endosperm Protein(Food & Nutrition)
- A New Peptidase Specific to D-Amino Acid Peptides from a Nocardia sp.
- Purification and Properties of a Peptidase from Nocardia orientalis Specific to D-Amino Acid Peptides(Biological Chemistry)
- Staurosporine, a Potent Plateltet Aggregation Inhibitor from a Streptomyces Species(Biological Chemistry)
- Antihypertensive Effect of Enzymatic Hydrolysate of Collagen and Gly-Pro in Spontaneously Hypertensive Rats
- In Vitro and in Vivo Anti-platelet Effects of Enzymatic Hydrolysates of Collagen and Collagen-related Peptides
- Prolylendopeptidase Inhibitory Activity of a Glial Fibrillary Acidic Protein Fragment and Other Proline-rich Peptides
- Prolyl Endopeptidase Inhibitory Activity of Peptides in the Repeated Sequence of Various Proline-Rich Proteins
- Angiotensin I-Converting Enzyme Inhibitors Derived from Ficus carica(Biological Chemistry)
- Actions of Teleocidins on in Vitro CFU-GM and CFU-E Colony Formation(Biological Chemistry)
- Prolonged Hydrogen Evolution by a Cyanobacterium (Blue-Green Alga), Anabaena sp.
- BACTERIAL DEGRADATION OF COMMERCIAL PCB MIXTURES (KANECLORS) AND THEIR METABOLITES
- 糸状菌によるラフィノースの分解に関する研究-3-酵素生産に及ぼす脂肪酸の促進効果〔英文〕
- New Parameters for Simulating Progress Curves of the Lipase Reaction
- Prolonged Photo-Hydrogen Production by Rhodospirillum rubrum
- Inhibition by Aloenin and Barbaloin of Histamine Release from Rat Peritoneal Mast Cells
- Incorporation of [14C]Methanol and [14C]Bicarbonate by Hyphomicrobium sp. 53-49 under Various Growth Conditions: Aerobic, Denitrifying and Autotrophic
- Construction of a Promoter-cloning Vector in Pseudomonas aeruginosa
- Autotrophic Growth of a Hyphomicrobium sp. and Its Hydrogenase Activity
- Comparison of the Key Enzymes of Hyphomicrobium sp. 53-49 under Various Growth Conditions: Aerobic, Denitrifying and Autotrophic
- Metabolism of Thiophene-2-carboxylate by a Photosynthetic Bacterium
- Angiotensin I-Converting Enzyme Inhibitor Derived from an Enzymatic Hydrolysate of Casein. II. Isolation and Bradykinin-potentiating Activity on the Uterus and the Ileum of Rats
- Studies on the Active Site and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitors Derived from Casein
- Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein
- A Peptide Inhibitor of Angiotensin I Converting Enzyme in the Tryptic Hydrolysate of Casein