Staurosporine, a Potent Plateltet Aggregation Inhibitor from a Streptomyces Species(Biological Chemistry)
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概要
- 論文の詳細を見る
We found a potent platelet aggregation inhibitor in the culture broth of Streptomyces strain M-193. The inhibitor was purified as white crystals and investigated; it was identified as staurosporine. It strongly inhibited the platelet aggregation induced by collagen or ADP with IC_<50> values of 3.4μM and 11.6μM, respectively. The inhibitor had no effect on thrombin-induced platelet aggregation or membrane stabilization against heat-induced hemolysis.
- 社団法人日本農芸化学会の論文
- 1986-11-23
著者
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Kodama M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Oka Syuichi
Fermentation Research Institute Agency Of Industrial Science And Technology
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Tomizuka Noboru
Fermentation Research Institute
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Takeda H
St. Catherine Women's Junior Coll. Hojo Jpn
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SUZUKI Hideo
Fermentation Research Institute
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Kaneko Motohisa
Biophysics Division National Cancer Center Research Institute
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KODAMA Mikiji
The Hokuren Federation of Agricultive Cooperatives
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TAKEDA Hiroyuki
The Hokuren Federation of Agricultive Cooperatives
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Suzuki Hideo
Fermentation Research Institute Agency Of Industrial Science And Technology
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